胰岛素抵抗及胰岛细胞功能与妊娠期糖尿病发生风险的相关性研究  

The relationship between insulin resistance,islet cell function and gestational diabetes mellitus

作　　者：邹瑞芳 刘岑 程华 ZOU Ruifang;LIU Cen;CHENG Hua(Department of Perinatal Health,Maternal and Child Health Hospital of Edong Medical Group,Huangshi 435000,Hubei,China;Department of Obstetrics,Maternal and Child Health Hospital of Edong Medical Group,Huangshi 435000,Hubei,China)

机构地区：[1]鄂东医疗集团市妇幼保健院围产保健科,湖北黄石435000 [2]鄂东医疗集团市妇幼保健院产科,湖北黄石435000

出　　处：《中国性科学》2022年第2期83-86,共4页Chinese Journal of Human Sexuality

基　　金：湖北省卫生健康委员会联合基金项目(WJ2019H482)。

摘　　要：目的研究胰岛素抵抗及胰岛细胞功能与妊娠期糖尿病(GDM)发生的相关性。方法选取2017年9月至2019年9月于鄂东医疗集团市妇幼保健院产检并分娩的222例孕妇作为研究对象,按是否发生GDM分为GDM组(n=69)与非GDM组(n=153)。检测两组孕妇的空腹血糖(FBG)水平､空腹胰岛素(FINS)水平及其他各项指标,并计算胰岛素抵抗指数(HOMA-IR)和胰岛细胞功能指数(HOMA-β),分析不同孕周HOMA-IR和HOMA-β的相关性及二者与GDM发生的相关性。结果非GDM组各孕期HOMA-IR显著低于GDM组对应孕期(P<0.05);GDM组各孕期HOMA-β显著低于非GDM组对应孕期(P<0.05)。两组孕妇各孕期HOMA-IR比较,差异无统计学意义(P>0.05);而HOMA-β呈现递减趋势(P<0.05)。二元Logistic回归分析结果显示,HOMA-IR水平高是发生GDM的危险因素(P<0.05),HOMA-β水平高是发生GDM的保护因素(P<0.05)。结论胰岛素抵抗及胰岛细胞功能与GDM发生具有相关性,且胰岛素抵抗程度升高是发生GDM的危险因素,而胰岛细胞功能良好是发生GDM的保护因素。Objective To study the correlation between insulin resistance,islet cell function and gestational diabetes mellitus(GDM).Methods 222 pregnant women who were examined and delivered in Maternal and Child Health Hospital of Edong Medical Group from September 2017 to September 2019 were selected as the research objects,according to the occurrence of GDM,the pregnant women were divided into GDM group(n=69)and non GDM group(n=153).The fasting blood glucose(FBG)level,fasting insulin(FINS)level and other indexes were measured,and the insulin resistance index(HOMA-IR)and islet cell function index(HOMA-β)were calculated.The correlation between HOMA-IR and HOMA-βat different gestational weeks,and their correlation with GDM were analyzed.Results HOMA-IR in non GDM group was significantly lower than that in GDM group(P<0.05),HOMA-βduring pregnancy in GDM group was significantly lower than that in non-GDM group(P<0.05).There was no significant difference in HOMA-IR between the two groups(P>0.05),while HOMA-βshowed a decreasing trend(P<0.05).The results of binary Logistic regression analysis showed that the high level of HOMA-IR was the risk factor of GDM(P<0.05),HOMA-βhigh level was a protective factor for GDM(P<0.05).Conclusions Insulin resistance and insulin cell function are re-lated to the occurrence of GDM,and the increase of insulin resistance is the risk factor for GDM,while the good function of insulin cells is the protective factor of GDM.

关 键 词：孕期 胰岛素抵抗 胰岛细胞功能 妊娠期糖尿病 

分 类 号：R714[医药卫生—妇产科学]