电针治疗化疗所致恶心呕吐Meta分析  被引量:2

Meta-Analysis of Electroacupuncture Treatment for Chemotherapy-Induced Nausea and Vomiting

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作  者:张韵 裴丽霞 陈昊[4] 陈璐 周俊灵 孙建华[2,3] ZHANG Yun;PEI Li-xia;CHEN Hao;CHEN Lu;ZHOU Jun-ling;SUN Jian-hua(Affiliated Hospital of Nanjing University of Chinese Medicine,The first clinical medical college,Nanjing,Jiangsu,210029;Department of Acupuncture and Rehabilitation,The Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing,Jiangsu,210029;Key Laboratory of Acupuncture and Medicine Research of Ministry of Education,Nanjing,Jiangsu,210023;Affiliated Hospital of Nanjing University of Chinese Medicine,The second clinical medical college,Nanjing,Jiangsu,210029)

机构地区:[1]南京中医药大学附属医院,第一临床医学院,江苏南京210029 [2]南京中医药大学附属医院,针灸康复科,江苏南京210029 [3]南京中医药大学针药结合教育部重点实验室,江苏南京210023 [4]南京中医药大学附属医院,第二临床医学院,江苏南京210029

出  处:《按摩与康复医学》2022年第7期31-36,共6页Chinese Manipulation and Rehabilitation Medicine

基  金:国家自然基金青年项目(81804193);国家中医药管理局“中医药循证能力建设项目”(2019XZZX-ZJ008);江苏省中医药管理局领军人才项目(SLJ0206);江苏省中医院院级高峰人才项目(y2018rc05)。

摘  要:目的:系统评价电针治疗恶性肿瘤化疗后恶心呕吐的疗效。方法:计算机检索Cochrane Library、Pub Med、Web of Sciences、中国生物医学文献数据库、知网、维普、万方数据库中关于将电针用于治疗恶性肿瘤化疗后恶心呕吐的随机对照试验,检索时限为建库至2020年03月01日。采用Rev Man5.3软件进行Meta分析。结果:共纳入15篇文献,共1494名患者。分析发现:电针治疗延迟性呕吐的有效率优于对照组(MD=1.40, 95%CL[1.28,1.52], P<0.00001);电针治疗急性呕吐的有效率与对照组无明显差异(MD=1.03,95%CL[0.92,1.16],P=0.11);电针治疗后血清5-HT的含量低于对照组(MD=-0.37,95%CL[-0.69,-0.06],P=0.02);电针治疗后KPS评分高于对照组(MD=5.57,95%CL[3.67,7.46],I2=68%),临床异质性较高,根据取穴不同进行亚组分析,电针穴组(MD=3.96,95%CL[1.85,6.08],I2=0%,P=0.0002),电针膈俞单穴(MD=12.28,95%CL[8.03,16.53],I;=0%,P<0.00001)。结论:电针治疗化疗所致恶心呕吐优于常规药物,值得在临床上应用推广。Objectives: Systematic review of the efficacy of electroacupuncture in the treatment of nausea and vomiting after chemotherapy for malignant tumors. Methods:Computer search for Cochrane Library, Pub Med, Web of Sciences, China Biomedical Literature Service System, China Knowledge Network, VIP and wan fang, collecting and sorting electroacupuncture treatment of nausea and vomiting after chemotherapy for malignant tumors randomized controlled trials. The retrieval time was from the establishment of the database to March 1, 2020. Using Rev Man5.3 software to perform the meta-analysis. Results: A total of 15 studies with 1494 patients were included. Meta-analysis results showed that the effective rate of electroacupuncture in the treatment of delayed vomiting was better than that of the control group(MD=1.40, 95%CL[1.28,1.52], P<0.00001);There was no significant difference between electroacupuncture and the control group in the effective rate of acute vomiting(MD=1.03, 95%CL[0.92,1.16], P=0.11>0.1);The 5-HT level in serum after electroacupuncture treatment is lower than that of the control group(MD=-0.37, 95%CL[-0.69,-0.06], P=0.02);Compared to the control group, patients received electroacupuncture showed a higher score in KPS(MD=5.57, 95%CL[3.67,7.46], I2=68%), clinical heterogeneity is high, according to the different point selection subgroup analysis, electroacupuncture point group(MD=3.96, 95%CL[1.85, 6.08], I2 =0%, P=0.0002), electroacupuncture geshu(MD=12.28, 95%CL[8.03, 16.53], I2 =0%, P<0.00001). Conclusion: Electroacupuncture is superior to conventional drugs in the treatment of chemotherapy-induced nausea and vomiting.It is worthy of clinical application and promotion.

关 键 词:电针 化疗 恶心呕吐 META分析 

分 类 号:R246.5[医药卫生—针灸推拿学]

 

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