滋阴补阳中药序贯疗法结合克罗米芬治疗多囊卵巢综合征不孕症35例  

Clinical effect of sequential Yin-nourishing and Yang-tonifying traditional Chinese medicine therapy combined with clomiphene in treatment of infertility due to polycystic ovary syndrome:An analysis of 35 cases

作　　者：白芳 王芬 吴福宁 BAI Fang;WANG Fen;WU Funing(Tongling Maternal and Child Health Hospital,Tongling 244099,Anhui,China;Wu Funing Workshop,Tongling Hospital of Traditional Chinese Medicine,Tongling 244000,Anhui,China)

机构地区：[1]铜陵市妇幼保健院,安徽铜陵244099 [2]铜陵市中医医院吴福宁工作室,安徽铜陵244000

出　　处：《湖南中医杂志》2022年第1期17-20,共4页Hunan Journal of Traditional Chinese Medicine

基　　金：安徽省中医药领军人才及培养对象项目(中医药发展秘[2018]23号)。

摘　　要：目的:探讨滋阴补阳中药序贯疗法结合克罗米芬治疗肾气亏虚型多囊卵巢综合征(PCOS)不孕症的临床疗效。方法:将70例肾气亏虚型PCOS不孕症患者随机分为治疗组和对照组,每组各35例。对照组采用克罗米芬治疗,治疗组在对照组的基础上联合滋阴补阳中药序贯疗法治疗。观察2组综合疗效,治疗前后血清卵泡刺激素(FSH)、雄激素(T)、黄体生成素(LH)水平,治疗周期、排卵周期、排卵率及妊娠率。结果:治愈率、总有效率治疗组分别为62.86%(22/35)、94.29%(33/35),均高于对照组的25.71%(9/35)、68.57%(24/35),差异有统计学意义(P<0.01,P<0.05)。2组FSH、T、LH水平治疗前后组内比较及治疗后组间比较,差异均有统计学意义(P<0.05,P<0.01)。2组治疗周期比较,差异无统计学意义(P>0.05);2组治疗后排卵周期、排卵率、妊娠率组间比较,差异均有统计学意义(P<0.01)。结论:滋阴补阳中药序贯疗法结合克罗米芬治疗肾气亏虚型PCOS不孕症,能有效改善患者激素水平,促进排卵,提高妊娠率,临床疗效确切。Objective:To investigate the clinical effect of sequential Yin-nourishing and Yang-tonifying traditional Chinese medicine(TCM)therapy combined with clomiphene in the treatment of infertility due to polycystic ovary syndrome(PCOS)with kidney-Qi deficiency.Methods:A total of 70 patients with infertility due to PCOS with kidney-Qi deficiency were randomly divided into treatment group and control group,with 35 patients in each group.The patients in the control group were given clomiphene,and those in the treatment group were given sequential Yin-nourishing and Yang-tonifying TCM therapy in addition to the treatment in the control group.The two groups were compared in terms of overall response,serum levels of follicle-stimulating hormone(FSH),testosterone(T),and luteinizing hormone(LH)before and after treatment,treatment cycle,ovulation cycle,ovulation rate,and pregnancy rate.Results:The treatment group had a cure rate of 62.86%(22/35)and an overall response rate of 94.29%(33/35),while the control group had a cure rate of 25.71%(9/35)and an overall response rate of 68.57%(24/35),and there were significant differences between the two groups(P<0.01,P<0.05).Both groups had significant changes in the levels of FSH,T,and LH after treatment,and there were significant differences in these indices between the two groups after treatment(P<0.05,P<0.01).There was no significant difference in treatment cycle between the two groups(P>0.05),while there were significant differences between the two groups in ovulation cycle,ovulation rate,and pregnancy rate after treatment(P<0.01).Conclusion:Sequential Yin-nourishing and Yang-tonifying TCM therapy combined with clomiphene has a marked clinical effect in the treatment of infertility due to PCOS with kidney-Qi deficiency and can effectively improve hormone levels,promote ovulation,and increase pregnancy rate.

关 键 词：多囊卵巢综合征 不孕症 肾气亏虚证 滋阴补阳 中药序贯疗法 克罗米芬 

分 类 号：R271.917.5[医药卫生—中西医结合] R271.916[医药卫生—中医妇科学]