呼吸机相关性肺损伤生物伤研究进展  

Research progresson the biotrauma of ventilator-induced lung injury

作　　者：欧顶琴 方育[1] OU Dingqin;FANG Yv(Department of Anesthesiology,The First Affiliated Hospital of Kunming Medical University,Yunnan,Kunming 650500,China)

机构地区：[1]昆明医科大学第一附属医院麻醉科,昆明市650500

出　　处：《河北医药》2022年第3期442-446,452,共6页Hebei Medical Journal

基　　金：国家自然科学基金(编号:81660456)。

摘　　要：机械通气是危重症患者呼吸支持的重要措施,但也可能导致呼吸机相关性肺损伤(ventilator-induced lung injury,VILI)。目前呼吸机相关性肺损伤中生物伤发生的机制尚不明确。深入研究生物伤的发生机制有助于临床防范和治疗肺损伤,为制定合理的通气策略提供新思路。文章拟从炎性反应、血气屏障功能障碍,内质网应激、氧化应激等方面对生物伤的研究进展作一综述。Mechanical ventilation is an important respiratory support measure for the patients with critically ill.However,mechanical ventilation may cause ventilator-induced lung injury(VILI).At present,the mechanism of biotrauma in VILI is unclear.To study the pathogenesis of biotrauma further can not only prevent and treat lung injury,but also provided new idea for instituting reasonable ventilation strategies.This article reviews the research progress of biotrauma from the aspects of inflammatory,blood-air barrier dysfunction,endoplasmic reticulum stress and oxidative stress.

关 键 词：呼吸机相关性肺损伤 生物伤 机制 

分 类 号：R563[医药卫生—呼吸系统]