骨痹汤熏蒸联合经筋推拿对膝骨关节炎患者关节功能及鞘氨醇激酶-1-磷酸鞘氨醇信号传导通路影响  

Effect of Gubi Decoction Fumigation Combined with Meridian Massage on Joint Function and SphK1-S1P Signal Transduction Pathway in Patients with Knee Osteoarthritis

作　　者：李阳[1] 李国丽 张丽曼[1] 张立颖[1] 王菲 狄生云 姜雪源 胡文杰[1] LI Yang;LI Guo-li;ZHANG Li-man;ZHANG Li-ying;WONG Fei;DI Sheng-yun;JIANG Xue-yuan;HUWen-jie(Department of Massage,Shijiazhuang Hospital of Traditional Chinese Medicine,Shijiazhuang Hebei 050051;Shijiazhuang Hetaiheng Hospital,Shijiazhuang Hebei 050051)

机构地区：[1]石家庄市中医院推拿科,河北石家庄050051 [2]石家庄市合泰恒医院,河北石家庄050051

出　　处：《世界中西医结合杂志》2022年第1期123-126,共4页World Journal of Integrated Traditional and Western Medicine

基　　金：河北省中医药管理局中医药类科研计划课题(2018231)。

摘　　要：目的探讨骨痹汤熏蒸联合经筋推拿对膝骨关节炎患者关节功能及鞘氨醇激酶-1(sphingosine kinase 1,SphK1)-磷酸鞘氨醇(sphingosine-1 phosphate,S1P)信号传导通路的影响。方法选取2018年5月—2020年5月期间在石家庄市中医院推拿科接受治疗的100例膝骨关节炎患者,按照随机数字表法分为研究组和对照组,每组各50例。对照组患者口服塞来昔布胶囊,研究组采用骨痹汤熏蒸联合经筋推拿。两组患者均连续治疗1个月后,观察比较两组患者疼痛程度及膝关节功能评分,采用双抗体夹心ABC-酶联免疫吸附法测定患者核转录因子-κB(Nuclear transcription factor-κB,NF-κB)、SphK1、S1P和基质金属蛋白酶-3(matrix metallo-proteinases-3,MMPs-3)水平。结果治疗后两组患者WOMAC量表评分均较治疗前降低,差异有统计学意义(P<0.05);且研究组较对照组明显降低,差异有统计学意义(P<0.05)。治疗后两组患者视觉模拟评分均较治疗前降低,差异有统计学意义(P<0.05);且研究组较对照组明显降低,差异有统计学意义(P<0.05)。治疗后两组患者NF-κB、SphK1、S1P和MMPs-3水平均较治疗前降低,差异有统计学意义(P<0.05);且研究组均低于对照组,差异有统计学意义(P<0.05)。治疗后研究组总有效率为94.00%(47/50),高于对照组72.00%(36/50),两组比较,差异有统计学意义(P<0.05)。结论骨痹汤熏蒸联合经筋推拿能够显著抑制膝骨关节炎患者SphK1-S1P信号传导通路,改善膝关节功能,减低患者疼痛程度,提高治疗效果。Objective To explore the effects of Gubi Decoction fumigation combined with meridian massage on joint function and sphingosine kinase 1(SphK1)-1-sphingosine-1 phosphate(S1 P)signaling pathway in patients with knee osteoarthritis Impact.Methods From May 2018 to May 2020,100 patients with knee osteoarthritis who received treatment in the Department of Tuina,Shijiazhuang Hospital of Traditional Chinese Medicine were selected and divided into a study group and a control group according to the random number table method,with 50 cases in each group.The patients in the control group were treated with celecoxib capsules orally,and the patients in the study group were treated with Gubi Tang fumigation combined with meridian massage.After continuous treatment for 1 month,the pain degree and knee joint function scores,the patient′s nuclear Transcription factor-κB(NF-κB),SphK1,S1 P and matrix metallo-proteinases-3(MMPs-3)levels of the two groups were observed and compared.Results After treatment,the WOMAC scale scores of the two groups of patients were lower than those before treatment,and the difference was statistically significant(P<0.05).After treatment,the visual analog scores of the two groups were lower than those before treatment,and the difference was statistically significant(P<0.05).After treatment,the levels of NF-κB,SphK1,S1 P and MMPs-3 in the patientswere all decreased,and the research group was lower than the control group,and the difference was statistically significant(P<0.05).After treatment,the total effective rate in the study group was 94.00%(47/50),which was higher than 72.00%(36/50)in the control group,and the difference was statistically significant(P<0.05).Conclusion Gubi Decoction fumigation combined with meridian massage can significantly inhibit the SphK1-S1 P signaling pathway in patients with knee osteoarthritis,improve knee joint function,reduce pain in patients,and improve treatment effects.

关 键 词：膝骨关节炎 经筋推拿 骨痹汤 关节功能 

分 类 号：R684.3[医药卫生—骨科学]