运脾化湿方对湿热证小儿急性非感染性腹泻病症状缓解及肠道微生态的影响  

Effects of Yunpi Huashi Decoction on Symptom Relief And Intestinal Microecology In Children With Acute Non-Infectious Diarrheal Disease(Damp-Heat Syndrome)

作　　者：李红艳[1] 李华[2] LI Hong-yan;LI Hua(Department of Pediatrics,First Central Hospital of Baoding City,Hebei Province,Baoding Hebei 071000;Department of Neurology,Affiliated Hospital of Hebei Engineering University,Handan Hebei 056001)

机构地区：[1]河北省保定市第一中心医院儿科,河北保定071000 [2]河北工程大学附属医院神经内一科,河北邯郸056001

出　　处：《世界中西医结合杂志》2022年第1期179-183,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：河北省科技计划项目(162777259)。

摘　　要：目的探讨运脾化湿方对小儿急性非感染性腹泻病(湿热证)症状缓解及肠道微生态的影响。方法选取2018年6月—2019年6月期间河北省保定市第一中心医院儿科收治的急性非感染性腹泻病(湿热证)患儿82例,采用随机数字表法将患者随机分为观察组和对照组,每组各41例。对照组给予西医常规治疗,观察组在对照组治疗基础上给予运脾化湿方口服治疗,3 d为1疗程,共治疗1个疗程。观察比较两组患儿治疗后临床疗效和基本临床指标复常时间,两组患儿治疗前后临床症状体征评分(大便次数、大便质地、大便性状、大便质量)、肠道菌群(乳杆菌、双歧杆菌、酵母样真菌、肠球菌)改善情况及不良反应情况。结果治疗后观察组总有效率为95.1%(39/41),对照组总有效率为75.6%(31/41)。两组比较,差异有统计学意义(P<0.05)。治疗后观察组大便次数及性状恢复正常时间、退热时间、呕吐停止时间、腹痛腹胀停止时间均明显低于对照组,两组比较,差异有统计学意义(P<0.05)。两组患儿治疗后大便次数、大便质地、大便性状、大便质量评分均较治疗前明显降低,差异有统计学意义(P<0.05);且观察组较对照组明显降低,差异有统计学意义(P<0.01)。两组患儿治疗后乳杆菌、双歧杆菌指标均较治疗前升高,肠球菌、酵母样真菌指标均较治疗前降低,差异有统计学意义(P<0.05);且观察组乳杆菌、双歧杆菌指标均较对照组明显升高,肠球菌、酵母样真菌指标均较对照组明显降低,差异有统计学意义(P<0.01)。治疗期间,两组患儿均未出现明显不良反应情况。结论运脾化湿方能够调节急性非感染性腹泻病(湿热证)患儿肠道菌群紊乱,有助于缓解患儿症状,促进疾病的预后转归,安全可靠。Objective To investigate the effect of Yunpi Huashi Decoction on symptom relief and intestinal microecology of acute non-infectious diarrheal disease(damp-heat syndrome)in children.Methods A total of 82 children with acute non-infectious diarrheal disease(damp-heat syndrome)admitted to the Department of Pediatrics of the First Central Hospital of Baoding City,Hebei Province from June 2018 to June 2019 were selected,and the patients were randomly divided into the observation group by the random number table method.and the control group,with 41 cases in each group.The control group was given conventional western medicine treatment,and the observation group was given the oral treatment of Yunpi Huashi Decoction based on the treatment of the control group.The clinical efficacy and the return time of basic clinical indicators of the two groups of children after treatment were observed and compared,the scores of clinical symptoms and signs(stool frequency,stool texture,stool character,stool quality),intestinal flora(Lactobacillus,bifidobacteria,yeast-like fungi,enterococcus)improvement and adverse reactions.Results After treatment,the total effective rate was 95.1%(39/41)in the observation group and 75.6%(31/41)in the control group.Comparing the two groups,the difference was statistically significant(P<0.05).After treatment,the time of stool frequency and character returning to normal,the time of antipyretic,the time to stop vomiting,the time to stop abdominal pain and abdominal distension=significantly lower than that of the control group.The difference was statistically significant(P<0.05).The scores of stoolfrequency,stool texture,stool character and stool quality of the two groups of children after treatment were significantly lower than those before treatment,and the difference was statistically significant(P<0.05);and the observation group Compared with the control group,the difference was statistically significant(P<0.01).After treatment,the indexes of Lactobacillus and Bifidobacterium in the two groups were inc

关 键 词：小儿急性腹泻 湿热证 运脾化湿方 肠道微生态 肠道菌群 

分 类 号：R722.132[医药卫生—儿科]