化痰逐瘀散结汤联合放化疗对Ⅲ期非小细胞肺癌患者免疫功能的影响  

Effect of Huatan Zhuyu Sanjie decoction combined with radiotherapy and chemotherapy on immune function in NSCLC patients with stageⅢ

作　　者：李明利 王承恩 杨丽辉[3] 王首星 LI Ming-li;WANG Cheng-en;YANG Li-hui;WANG Shou-xing(Department of Medical Oncology,Handan First Hospital,Handan,Hebei 056002,China;不详)

机构地区：[1]邯郸市第一医院肿瘤内科,河北邯郸056002 [2]北京医院肿瘤微创治疗中心,北京100730 [3]邯郸市第一医院门诊部,河北邯郸056002 [4]邯郸市第一医院普外七科,河北邯郸056002

出　　处：《中国临床研究》2022年第2期234-237,共4页Chinese Journal of Clinical Research

基　　金：河北省中医药类科研计划课题(2019385)。

摘　　要：目的探讨化痰逐瘀散结汤联合放化疗对Ⅲ期非小细胞肺癌患者免疫功能及生活质量的影响。方法将2018年6月到2020年1月邯郸市第一医院收治的86例Ⅲ期非小细胞肺癌患者随机分配到研究组与对照组,各43例。研究组患者行化痰逐瘀散结汤联合放化疗治疗,对照组患者仅接受放化疗。所有患者于治疗完成后进行评价,比较两组患者机体免疫功能指标、生活质量评分和毒副反应情况。结果治疗后,研究组KPS评分改善情况优于对照组(P<0.01)。研究组骨髓抑制、消化道反应、放射性肺炎发生情况少于对照组,差异有统计学意义(P<0.05,P<0.01)。研究组CD3^(+)细胞、CD4^(+)细胞、CD4^(+)/CD8^(+)比值、IgG、IgM和IgA高于治疗前及对照组水平(P<0.05)。结论对Ⅲ期非小细胞肺癌患者,采用化痰逐瘀散结汤联合放化疗治疗可以提高患者机体免疫功能、改善生活质量及减轻毒副反应。Objective To investigate the effect of Huatan Zhuyu Sanjie Decoction(HZSD)combined with radiotherapy and chemotherapy on immune function and quality of life in patients with stageⅢnon-small cell lung cancer(NSCLC).Methods A total of 86 patients with stageⅢNSCLC treated in Handan First Hospital from June 2018 to January 2020 were randomly assigned to the study group and the control group(n=43,each).HZSD combined with radiotherapy and chemotherapy was given in study group,while the radiotherapy and chemotherapy were conducted alone in control group.Immune function,quality of life score and toxic and side effects were compared after treatment between two groups.Results The improvement of Karnofsky performance scale(KPS)score in study group was significantly superior to that in control group(P<0.01).The incidence of bone marrow suppression,gastrointestinal reaction and radiation pneumonia in study group was significantly lower than that in control group(P<0.05,P<0.01).The levels of CD3,CD4,CD4/CD8 ratio as well as IgG,IgM and IgA in study group were significantly higher than those before treatment and those in control group(P<0.05).Conclusion Huatan Zhuyu Sanjie decoction combined with radiotherapy and chemotherapy can enhance the immune function,improve the quality of life,and reduce the side effects for the patients with stageⅢNSCLC.

关 键 词：化痰逐瘀散结汤 放化疗 肺癌 免疫功能 

分 类 号：R273[医药卫生—中西医结合]