艾塞那肽改善肥胖2型糖尿病患者生存质量的研究  

Improvements in quality of life with Exenatide treatment in obesity patients with type 2 diabetes mellitus

作　　者：陈亚宁 胡晓东[1] 赵明伟 姚合斌[1] CHEN Yaning;HU Xiaodong;ZHAO Mingwei(Department of Endocrinology,The Sixth Medical Center of PLA General Hospital,Beijing 100048,China)

机构地区：[1]北京解放军总医院第六医学中心内分泌科,北京100048

出　　处：《中国糖尿病杂志》2022年第2期106-110,共5页Chinese Journal of Diabetes

基　　金：2018年宜昌市医疗卫生科研项目(A18-301-37)。

摘　　要：目的探讨艾塞那肽注射治疗对肥胖T2DM患者生存质量的影响。方法纳入22例肥胖T2DM患者,采用36项简式健康调查和世界卫生组织生存质量测定简表评估患者基线和艾塞那肽注射治疗26周后的生存质量。结果2例患者退出试验。与基线比较,治疗26周后,体重、WC、FPG、HbA_(1)c均降低(P<0.05或P<0.01),躯体功能、情绪健康问题导致的角色限制、躯体健康领域(PHYS)、心理领域、社会关系领域和环境领域评分均升高(P<0.05或P<0.01)。Pearson相关分析显示,HbA_(1)c与PHYS呈负相关(r=-0.735,P=0.006)。结论艾塞那肽注射治疗能降低肥胖T2DM患者血糖和体重,并改善总体生存质量。ObjectiveTo investigate the effect of Exenatide injection on the quality of life inobese patients with type 2 diabetes mellitus(T2 DM).enrolled in this observational study.They were treated with Exenatide and followed up for 26 weeks.Quality of life was measured by SF-36 and WHOQOL-BREF at baseline and after 26 weeks of Exenatide therapy.ResultsTwo patients withdrew from the trial.Compared with baseline,after 26 weeks of treatment,body weight,WC,FPG and HbA_(1)c all decreased(P<0.05 or P<0.01),and physical function,role restriction caused by emotional health problems,physical health(PHYS),psychological,social relations and environmental fields were increased(P<0.05 or P<0.01).Pearson correlation analysis showed that HbA_(1)c was negatively correlated with PHYS(r=-0.735,P=0.006).the blood glucose and body weight significantly but also greatly improve the quality of life in obesity patients with T2 DM.

关 键 词：糖尿病 2型 艾塞那肽 肥胖 生存质量 36项简式健康调查 世界卫生组织生存质量测定简表 

分 类 号：R587.2[医药卫生—内分泌] R589.2[医药卫生—内科学]