加味桂枝茯苓汤对子宫内膜异位症手术患者氧化应激状态、卵巢储备功能和远期妊娠率的影响  

Effects of Modified Guizhi Fuling Decoction on Oxidative Stress State, Ovarian Reserve and Long-term Pregnancy Rate in Patients Undergoing Endometriosis Surgery

作　　者：陈莉[1] 田斌斌[1] 张勤华 陈琰[1] 顾卫华[1] CHEN Li;TIAN Binbin;ZHANG Qinhua;CHEN Yan;GU Weihua(Taizhou Hospital of TCM,Taizhou 225300,China;不详)

机构地区：[1]泰州市中医院,江苏泰州225300 [2]上海市第一妇婴保健院

出　　处：《中外医学研究》2022年第4期56-60,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨加味桂枝茯苓汤对子宫内膜异位症(endometriosis,EMS)手术患者氧化应激状态、卵巢储备功能和远期妊娠率的影响。方法:选取2018年2月-2019年1月上海市第一妇婴保健院妇科门诊收治的EMS手术患者90例。按病历号随机分成观察组和对照组,每组45例。观察组给予孕三烯酮联合加味桂枝茯苓汤治疗,对照组给予孕三烯酮治疗,两组治疗3个月。比较两组治疗前后氧化应激指标[超氧化物歧化酶(superoxide dismutase,SOD)、活性氧(reactive oxygen species,ROS)、丙二醛(malondialdehyde,MDA)、谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)]、性激素指标[血清卵泡刺激素(follicle stimulating hormone,FSH)、黄体生成素(luteinizing hormone,LH)、血清雌二醇(estradiol,E_(2))、孕酮(progesterone,P)]和远期妊娠情况。结果:治疗前,两组SOD、ROS、MDA、GSH-Px、FSH、LH、E_(2)、P水平比较差异均无统计学意义(P>0.05),治疗后,观察组SOD、GSH-Px水平均高于对照组(P<0.05),MDA、ROS、FSH、LH、E_(2)、P水平均低于对照组(P<0.05);治疗后,随访2年内观察组妊娠率高于对照组,差异有统计学意义(P<0.05)。结论:加味桂枝茯苓汤对子宫内膜异位症手术患者的氧化应激状态、卵巢储备功能改善效果好,有利于提高远期妊娠率。Objective:To investigate the effects of Modified Guizhi Fuling Decoction on oxidative stress state,ovarian reserve and long-term pregnancy rate in patients undergoing endometriosis (EMS) surgery.Method:A total of 90 patients undergoing EMS surgery admitted to the gynecology outpatient of Shanghai First Maternity and Infant Hospital from February 2018 to January 2019 were selected.According to the medical record number,they were randomly divided into observation group and control group,45 cases in each group.The observation group was given Gestrinone combined with Modified Guizhi Fuling Decoction treatment,and the control group was given Gestrinone treatment,the two groups were treated for 3 months.The oxidative stress indexes[superoxide dismutase (SOD),reactive oxygen species (ROS),malondialdehyde (MDA),glutathione peroxidase (GSH-Px)],sex hormone indexes[serum follicle stimulating hormone (FSH),luteinizing hormone (LH),serum estradiol (E_(2)),progesterone (P)]before and after treatment and long-term pregnancy condition of the two groups were compared.Result:Before treatment,there were no significant differences in the levels of SOD,ROS,MDA,GSH-Px,FSH,LH,E_(2)and P between the two groups (P>0.05).After treatment,the levels of SOD,GSH-Px in the observation group were higher than those in the control group (P<0.05),the MDA,ROS,FSH,LH,E_(2)and P levels in the observation group were lower than those in control group (P<0.05).After treatment,the pregnancy rate in the observation group was higher than that in the control group within 2 years of follow-up,the difference was statistically significant (P<0.05).Conclusion:The Modified Guizhi Fuling Decoction has a good effect on the improvement of oxidative stress state and ovarian reserve in patients undergoing EMS surgery,which is beneficial to improve the long-term pregnancy rate.

关 键 词：子宫内膜异位症 手术 卵巢储备功能 远期妊娠率 氧化应激状态 加味桂枝茯苓汤 

分 类 号：R713.4[医药卫生—妇产科学]