新型苯并咪唑衍生物的合成  

Synthesis of Novel Benzimidazole Derivatives

作　　者：何冠宁 袁斌[1] 贾群坡 吕松[1] HE Guan-ning;YUAN Bin;JIA Qun-po;LV Song(Facultyof Environmental Science and Engineering, Guangdong University of Technology, Guangzhou 510006, China)

机构地区：[1]广东工业大学环境科学与工程学院,广东广州510006

出　　处：《合成化学》2022年第2期107-112,共6页Chinese Journal of Synthetic Chemistry

基　　金：广东省科技计划项目(2016A020221035)。

摘　　要：以苯甲醛甘油缩醛和对甲基苯甲醛甘油缩醛为原料,采用次氯酸钠催化氧化法,制得2-芳基-4-羧基-1,3-二氧戊环中间体;中间体分别与邻苯二胺或N-甲基邻苯二胺反应,合成了4种新型苯并咪唑衍生物(3a~3d),收率为78.0%~80.5%,其结构经UV-Vis,^(1)H NMR,^(13)C NMR,IR和HR-MS(ESI)表征。The intermediates of 2-aryl-1,3-dioxolame-4-carboxyl acid were synthesized by the catalytic oxidation method of sodium hypochlorite using benzaldehyde glycerol acetal and p-methylbenzaldehyde glycerin acetal as raw material.Four novel benzimidazole derivatives were synthesized efficiently by the intermediate reacted with o-phenylenediamine or N-methyl-o-phenylenediamine respectively.Compounds 3a,3b,3c,3d were new substances.The yields were 79.5%,78.0%,80.5%and 78.0%,respectively.The structures were characterized by UV-Vis,^(1)H NMR,^(13)C NMR,IR and HR-MS(ESI).The synthesis conditions of new compounds were optimized by orthogonal test.

关 键 词：甘油缩醛 苯并咪唑 1 3-二氧戊环 邻苯二胺 合成 催化氧化 

分 类 号：O626.23[理学—有机化学]