水相铜催化α-酮酸与邻氨基苯硫酚合成苯并噻唑化合物  

Copper-catalyzed Synthesis of Benzothiazoles from α-Keto Acids to ortho-Aminothiophenol in Water

作　　者：赖胤龙 周丽珍[1,2] 陈梓深 杜煜龙 李秋燕 谢汉非 张琦 严绍熙 LAI Yin-long;ZHOU Li-zhen;CHEN Zi-shen;DU Yu-long;LI Qiu-yan;XIE Han-fei;ZHANG Qi;YAN Shao-xi(College of Chemistry and Civil Engineering, Shaoguan University, Shaoguan 512005, China;Shaoguan Ecological Environment Monitoring Center Station of Guangdong Province, Shaoguan 512005, China)

机构地区：[1]韶关学院化学与土木工程学院,广东韶关512005 [2]广东省韶关生态环境监测中心站,广东韶关512005

出　　处：《合成化学》2022年第2期113-119,共7页Chinese Journal of Synthetic Chemistry

基　　金：广东省科技创新战略专项(韶科〔2020〕44号);广东省自然科学基金面上资助项目(2021A1515010185);广东省普通高校科研项目(2018KQNCX236);广东省高等教育学会实验室管理专业委员会项目(GDJ2019135)。

摘　　要：发展了一种新颖的水相α-酮酸与邻氨基苯硫酚合成苯并噻唑化合物的方法。在CuCl_(2)·2H_(2)O的催化下,通过该反应顺利合成了2-取代苯并噻唑化合物,产率较高,底物适应性较好。A new route for the synthesis of benzothiazoles fromα-Keto Acids and o-aminothiophenol in water has been developed.Catalyzed by CuCl_(2)·2H_(2)O,the reaction proceeds smoothly under air to afford 2-substituted benzothiazoles in good to excellent yields with a wide substrate scope.

关 键 词：水相 铜催化 苯并噻唑 Α-酮酸 邻氨基苯硫酚 合成 

分 类 号：O6[理学—化学]