5-氨基异噁唑的4-位芳基化  

The 4-Position Arylation of 5-Amino-isoxazoles

作　　者：刘辉 张晓梅[1,2] LIU Hui;ZHANG Xiao-mei(Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China;Department of Chemistry, Xihua University, Chengdu 610039, China;University of Chinese Academy of Sciences, Beijing 100049, China)

机构地区：[1]中国科学院成都有机化学研究所,四川成都610041 [2]西华大学化学系,四川成都610039 [3]中国科学院大学,北京100049

出　　处：《合成化学》2022年第2期126-132,共7页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(21672208)。

摘　　要：在温和、简单条件下实现了5-氨基异噁唑C4位芳基化的反应,以中等到优秀的产率(最高达99%)合成了一系列4-芳基-5-氨基异噁唑类衍生物,产物结构经核磁与高分辨质谱确证。The arylation of 5-amino-isoxazoles with quinone monoimines was realized using phosphoric acid as catalyst.Various novel 4-aryl-5-amino-isoxazole dericatives were achieved in moderate to good yields(up to 99%).The structures were confirmed by NMR and HR-MS.

关 键 词：5-氨基异噁唑 对苯醌单亚胺 芳基化 合成 

分 类 号：O62[理学—有机化学]