机械灌注在公民逝世后器官捐献供肾质量维护方面的应用研究进展  

Research progress on application of machine perfusion in quality maintenance of donor kidney from organ donation after citizen’s death

作　　者：昌盛 代林睿 Chang Sheng;Dai Linrui(Institute of Organ Transplantation,Tongji Hospital,Tongji Medical College,Huazhong University ofScience and Technology,Wuhan 430030,China)

机构地区：[1]华中科技大学同济医学院附属同济医院器官移植研究所,武汉430030

出　　处：《器官移植》2022年第2期195-205,共11页Organ Transplantation

基　　金：国家自然科学基金(81873511)。

摘　　要：公民逝世后器官捐献目前已成为我国器官捐献的主要来源,但是由于供者质量的复杂性,扩大标准供者(ECD)供肾占比增加,从而对供肾的可利用性以及肾移植受者术后的长期预后造成很大的影响。加强供肾质量的维护与评估,对于改善供肾质量、增加供肾获取与利用、改善受者和移植肾长期存活具有重要意义。机械灌注保存作为器官保存的重要方式之一,不但可以延长供肾保存的时间,改善供肾质量,而且在供肾修复及功能评估方面具有重要作用。本文结合文献介绍了机械灌注在公民逝世后器官捐献供肾质量维护中的一些热点问题及对应的处理方案与进展,旨在为选择供肾的最佳保存方式,提高ECD供肾质量和利用率提供参考。Organ donation after citizen’s death has become the main source of organ donation in China.However,the complexity of donor quality and the increasing proportion of expanded criteria donor(ECD)exert significant impact upon the availability of donor kidney and the long-term prognosis of recipients after kidney transplantation.Strengthening the quality maintenance and evaluation of donor kidney is of great significance for improving the quality of donor kidney,increasing the procurement and utilization of donor kidney and prolonging the long-term survival of recipients and kidney allografts.As one of the major approaches of organ preservation,machine perfusion preservation may not only prolong the preservation time and improve the quality of donor kidney,but also play a critical role in the repair and function evaluation of donor kidney.Based on literature review,several hot issues,corresponding treatment strategies and research progress on machine perfusion in the quality maintenance of donor kidney from organ donation after citizen’s death were reviewed in this article,aiming to provide reference for selecting the optimal preservation method of donor kidney and enhancing the quality and utilization rate of ECD donor kidney.

关 键 词：肾移植 公民逝世后器官捐献 扩大标准供者 低温机械灌注(HMP) 体外常温机械灌注(EVNP) 腹部区域机械灌注(ARP) 静态冷保存(SCS) 体外膜肺氧合 

分 类 号：R617[医药卫生—外科学] R692[医药卫生—临床医学]