促进脂肪来源间充质干细胞成骨分化的诱导方法研究进展  

Advances on strategies for promoting osteogenic differentiation of adipose-derived mesenchymal stem cells

作　　者：杜青晏 顾洛莎 赵高峰[1] 史珂 刘林嶓[1] 张建文[1] Du Qingyan;Gu Luosha;Zhao Gaofeng;Shi Ke;Liu Linbo;Zhang Jianwen(Department of Plastic Surgery,First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院整形外科,郑州450052

出　　处：《中华整形外科杂志》2022年第1期98-103,共6页Chinese Journal of Plastic Surgery

摘　　要：脂肪来源间充质干细胞(ASCs)是一种多能成体干细胞,因安全、含量丰富、易于获取等优点而有望成为理想的骨组织工程(BTE)种子细胞。然而,相较于骨髓间充质干细胞,ASCs的成骨分化能力有限,往往需要进一步诱导。该文从优化支架、添加生物活性因子或促成骨药物、非编码RNA调控和物理刺激几个方面,对促进ASCs成骨分化的诱导方法的研究进展进行综述,以期为BTE研究提供参考。Adipose-derived mesenchymal stem cells(ASCs)are pluripotent adult mesenchymal stem cells that are expected to be ideal seed cells for bone tissue engineering(BTE)due to their biosecurity,abundance,and easy access.However,in comparison with bone marrow mesenchymal stem cells,ASCs possess a relatively limited osteogenic capacity and often require further induction.Advances on strategies for promoting osteogenic differentiation of ASCs are reviewed from following aspects:optimization of scaffolds,addition of bioactive factors or drugs,non-coding RNA regulation,and physical stimulation,so as to provide references for the use of ASCs in BTE.

关 键 词：脂肪组织 间充质干细胞 成骨诱导 组织工程 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]