Decorating rare-earth fluoride upconversion nanoparticles on AuNRs@Ag core-shell structure for NIR light-mediated photothermal therapy and bioimaging  

作　　者：Jingzhi Dou Bei Chen Guixia Liu Xiangting Dong Wensheng Yu Jinxian Wang Yunxiao Zhang Zhanguo Li Jiang Zhu 

机构地区：[1]Key Laboratory of Applied Chemistry and Nanotechnology at Universities of Jilin Province,Changchun University of Science and Technology,Changchun 130022,China [2]Key Laboratory of Artificial Micro-and Nano-Structures of Ministry of Education,School of Physics and Technology,Wuhan University,Wuhan 430072,China [3]Tianjin Jinhang Technical Physics Institute,Tianjin 300070,China [4]School of Optoelectronic Engineering,Changchun University of Science and Technology,Changchun 130022,China [5]School of Foreign Languages,Changchun University of Science and Technology,Changchun 130022,China

出　　处：《Journal of Rare Earths》2022年第2期193-200,I0001,共9页稀土学报（英文版）

基　　金：Project supported by National key R&D Program of China(2019YFA0705204);National Natural Science Foundation of China(51072026,51573023,51802027)。

摘　　要：Photothermal therapy(PTT)has presented its inherent application value in cancer treatment.Nevertheless,single-functional photothermal materials cannot meet the precise diagnosis and treatment of cance r.Therefo re,it is important to design a nanocomposite that has both high therapeutic efficiency and multimodal imaging capabilities.In our work,a new nanostructure of gold nanorods(AuNRs)with silver shells decorated by BaGdF5:Yb^(3+),Er^(3+)nanoparticle was synthesized by a simple way.The biostability of AuNRs is increased by coating with silver shells,and the AuNR@Ag nanoparticles can be used as excellent surface enhanced Raman scattering(SERS)probe.Moreover,the modification of BaGdF5:Yb^(3+),Er^(3+)nanoparticles provides the possibility of real-time optical imaging of the tumor area.Under the irradiation of NIR laser,the AuNR@Ag/BaGdF5:Yb^(3+),Er^(3+)nanocomposites(NCs)have strong upconversion emission and excellent photothermal conversion efficiency.Meanwhile,the NCs show low cytotoxicity and good biocompatibility in MTT cytotoxicity test.Moreover,the NCs are also exceptional contrast agents for CT imaging.For in vitro photothermal therapy test,NCs show excellent killing efficiency on tumor cells.Therefore,the multifaceted research of AuNR@Ag/BaGdF5:Yb^(3+),Er^(3+)multifunctional nanomaterials provides a break for high-efficiency tumor photothermal therapy and multimodal imaging.

关 键 词：Multifunctional nanocomposites Photothermal therapy Multimodal imaging Rare earths 

分 类 号：TB33[一般工业技术—材料科学与工程] R318.08[医药卫生—生物医学工程]