依地酸钙钠静脉注射与口服二巯丁二酸对儿童铅中毒的疗效比较  

Comparison of Therapeutic Effects of Calcium Disodium Edetate Intravenous Injection and Oral Dimercaptosuccinic Acid on Lead Poisoning in Children

作　　者：林洪滨 LIN Hongbin(Shenzhen Longgang District People’s Hospital,Shenzhen 518172,China)

机构地区：[1]深圳市龙岗区人民医院,广东深圳518172

出　　处：《中外医学研究》2022年第5期55-58,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨使用依地酸钙钠静脉注射及口服二巯丁二酸治疗儿童铅中毒的效果及对不良反应的影响。方法:选择2018年1月-2020年12月98例在深圳市龙岗区人民医院治疗的铅中毒患儿作为研究对象,按照治疗方式分为研究组和对照组,各49例。对照组采用依地酸钙钠(CaNa;EDTA)静脉注射治疗,研究组采取口服二巯丁二酸治疗。对比两组治疗效果,不良反应发生率,总胆固醇、甘油三酯及低密度脂蛋白水平,住院费用及家长满意度。结果:研究组与对照组治疗效果比较,差异无统计学意义(P>0.05);研究组不良反应发生率略低于对照组,差异无统计学意义(P>0.05);治疗后,研究组总胆固醇、甘油三酯及低密度脂蛋白水平较对照组低,差异无统计学意义(P>0.05);研究组总住院费用显著低于对照组(P<0.05);研究组患儿家长满意度显著高于对照组(P<0.05)。结论:对铅中毒患儿采用口服二巯丁二酸及依地酸钙钠静脉注射驱铅均可以取得一定的治疗效果,但口服二巯丁二酸治疗产生的费用更低,家长满意度更高。Objective:To investigate the efficacy and adverse effects of intravenous Calcium Disodium Edetate and oral Dimercaptosuccinic Acid in children with lead poisoning.Method:A total of 98 children with lead poisoning treated in Shenzhen Longgang District People’s Hospital from January 2018 to December 2020 were selected as the study subjects,they were divided into study group and control group according to the treatment method,with 49 children in each group.The control group was performed by Calcium Disodium Edetate (CaNa;EDTA) intravenous injection,the study group was taken oral Dimercaptosuccinic Acid treatment.The treatment efficacy,incidence of adverse reactions,total cholesterol,triglyceride and low density lipoprotein levels,hospitalization costs and parental satisfaction were compared between the two groups.Result:There was no significant difference in treatment effect between the study group and the control group (P>0.05).The incidence of adverse reactions in the study group was slightly lower than that in the control group,with no statistical significance (P>0.05).After treatment,the total cholesterol,triglycerides,and low density lipoprotein levels in the study group were lower than those in the control group,and the differences were not statistically significant (P>0.05).The total hospitalization cost in the study group was significantly lower than that in the control group (P<0.05).The parent satisfaction in the study group was significantly higher than that of the control group (P<0.05).Conclusion:Both oral Dimercaptosuccinic Acid and intravenous Calcium Disodium Edetate can achieve certain therapeutic effects in children with lead poisoning,but oral Dimercaptobutanoic Acid treatment generates less cost and greater parental satisfaction.

关 键 词：二巯丁二酸 铅中毒 儿童患者 依地酸钙钠 住院费用 

分 类 号：R725.9[医药卫生—儿科]