NGF/TrKA信号通路在膝骨关节炎疼痛中的研究进展  

Research progress of NGF/TrKA signaling pathway in knee osteoarthritis pain

作　　者：李明超 王培民[2] 殷松江[2] 张力[2] 黄正泉[2] 邢润麟 LI Mingchao;WANG Peimin;YIN Songjiang;ZHANG Li;HUANG Zhengquan;XING Runlin(Department of Orthopaedics,the Third People’s Hospital of Kunshan,Jiangsu Province,Kunshan215300,China;Department of Orthopaedics,Affiliated Hospital of Nanjing University of Chinese Medicine,Jiangsu Province,Nanjing210029,China)

机构地区：[1]江苏省昆山市第三人民医院骨科,江苏昆山215300 [2]南京中医药大学附属医院骨伤科,江苏南京210029

出　　处：《中国医药导报》2022年第5期36-39,55,共5页China Medical Herald

基　　金：国家自然科学基金面上项目(82074460);江苏省苏州市科技发展计划项目(SYS2020059、SKJYD2021024)。

摘　　要：疼痛是膝关节骨关节炎(KOA)的主要症状,慢性疼痛严重影响患者生活质量。KOA疼痛涉及炎症环境、软骨损伤、神经敏化等病理性改变。近期研究显示,阻断神经生长因子(NGF)可成功减轻KOA疼痛,证实NGF是膝关节骨关节炎疼痛的关键机制。本文针对NGF/原肌球蛋白受体激酶A信号通路与KOA疼痛相关病理性改变的研究进展作一综述。Pain is the main symptom of knee osteoarthritis(KOA),chronic pain seriously affects the quality of life of patients.KOA pain involves pathological changes such as inflammatory environment,cartilage damage,and nerve sensitization.Recent studies have shown that blocking nerve growth factor(NGF)successfully alleviates PAIN in KOA,confirming that NGF is a key mechanism of pain in knee osteoarthritis.This article reviews the research progress of NGF/Tropomyosin receptor kinase A signaling pathway and pathologic changes related to KOA pain.

关 键 词：膝关节骨性关节炎 疼痛 神经生长因子 原肌球蛋白受体激酶A 

分 类 号：R684[医药卫生—骨科学]