基于数据挖掘的《中华医典》中肺纤维化的用药规律研究  

Study on the regularity of drug use of Chinese Medical Code in the treatment of pulmonary fibrosis based on data mining

作　　者：肖锶瑶 于洋[2] 熊轶敏 刘莹芳 张纾难[2] XIAO Siyao;YU Yang;XIONG Yimin;LIU Yingfang;ZHANG Shunan(Graduate School,Beijing University of Chinese Medicine,Beijing100029,China;Department of Traditional Chinese Medicine for Pulmonary Diseases of Respiratory Medicine Center of China-Japan Friendship HospitalNational Center for Respiratory MedicineInstitute of Respiratory Medicine of Chinese Academy of Medical SciencesNational Clinical Research Center for Respiratory DiseasesCollaborating Centre for WHO Tobacco Cessation and Respiratory Diseases Prevention,Beijing100029,China)

机构地区：[1]北京中医药大学研究生院,北京100029 [2]中日友好医院呼吸中心中医肺病科,国家呼吸医学中心,中国医学科学院呼吸病学研究院,国家呼吸疾病临床医学研究中心,世界卫生组织戒烟与呼吸疾病预防合作中心,北京100029

出　　处：《中国医药导报》2022年第5期159-162,共4页China Medical Herald

基　　金：国家自然科学基金资助项目(81804044)。

摘　　要：目的探讨《中华医典》中治疗肺纤维化方剂的用药特点和处方规律。方法以“肺痿”“肺痹”“喘证”为检索词搜索《中华医典》中治疗肺纤维化的处方,通过阅读文献资料对处方进行筛选,使用Excel 2010对纳入处方进行数据提取和建立药物数据库,应用SPSS Statistics 20.0和SPSS Molder 18.0挖掘处方中的组方用药规律。结果研究最终纳入处方102首,中药108味,药物总频次813次,使用频率≥10%的药物24味。处方中的核心配伍药物包括甘草、人参、茯苓、桔梗、川贝母、紫菀、款冬花等。结论以补益肺脾为核心,结合温中或清热,辅以平喘、降气、化痰、止咳等治法是《中华医典》中治疗肺纤维化的组方规律。Objective To explore the drug use characteristics and prescription regularity in the treatment of pulmonary fibrosis in Chinese Medical Code.Methods“Lung atrophy”“Pulmonary arthralgia”“dyspnea syndrome”as the key words,the prescriptions about the treatment of pulmonary fibrosis in Chinese Medical Code were searched,and the prescriptions were screened by reading the literatures.Excel 2010 was used to extract the data of the prescriptions and to establish the drug database,SPSS Statistics 20.0 and SPSS Molder 18.0 were used to mine the rules of prescription medication.Results The study finally included 102 prescriptions,108 Chinese herbs,the total frequency of drugs was 813,and the use drugs with the frequency≥10%were 24.The core compatibility drugs in the prescription include Radix Glycyrrhizae,Radix Ginseng,Poria,Radix Platycodonis,Bulbus Fritillariae Cirrhosae,Radix Asteris,Flos Farfarae,and so on.Conclusion Taking tonifying lung and spleen as the core,combined with warming or clearing heat,supplemented by relieving asthma,reducing qi,resolving phlegm,relieving cough,and other treatment are the prescription regularity for the treatment of pulmonary fibrosis in Chinese Medical Code.

关 键 词：数据挖掘 肺纤维化 中医 中药 用药规律 

分 类 号：R563.9[医药卫生—呼吸系统]