基于唾液检测病毒感染性生物标志物的研究进展  

Advances in saliva-based detection of viral infectious biomarkers

作　　者：余舒星 邹静[1,2] 李雨庆[1] Yu Shuxing;Zou Jing;Li Yuqing(State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&West China School of Stomatology,Sichuan University,Chengdu 610041,China;State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Dept.of Pediatric Dentistry,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)

机构地区：[1]口腔疾病研究国家重点实验室,国家口腔疾病临床医学研究中心,四川大学华西口腔医学院,成都610041 [2]口腔疾病研究国家重点实验室,国家口腔疾病临床医学研究中心,四川大学华西口腔医院儿童口腔科,成都610041

出　　处：《国际口腔医学杂志》2022年第2期189-196,共8页International Journal of Stomatology

基　　金：四川大学新型冠状病毒应急项目(2020scunCoV-10008)。

摘　　要：唾液具有清洁、消化和抑菌等多种功能,其成分可因病毒等感染而发生变化。唾液成分可包含多种病毒感染的生物标志物,如DNA、RNA、抗体和抗原等。随着现代科学技术的突破性发展,各种生物标志物的检出使得利用唾液样本辅助诊断病毒感染成为可能。唾液样本具有无侵入性、方便易取的优势,逐渐成为了病毒感染检测领域的研究热点。本文将围绕该领域的研究进展进行综述。Saliva has a variety of functions,such as cleansing,digestion,and bacterial inhibition.Its composition can be altered by infections,such as viruses.Saliva components can contain a variety of biomarkers of viral infections,such as DNA,RNA,antibodies,and antigens.With the breakthroughs in modern science and technology,the detection of va rious biomarkers has made possible the utilization of saliva samples in aiding in the diagnosis of viral infections.With the advantages of non-invasive and easy access,saliva samples have gradually become a research hotspot in the field of viral infection detection.This article will review the research progress in this field.

关 键 词：唾液 病毒感染性生物标志物 检测 

分 类 号：R446.1[医药卫生—诊断学] R511[医药卫生—临床医学]