合肥市246例新生儿窒息相关临床风险因素  

Related clinical risk factors of 246 neonatal asphyxia in Hefei

作　　者：张友军 陈红波[1] 陶峰[1] ZHANG Youjun;CHEN Hongbo;TAO Feng(Department of Obstetrics and Gynecology,Maternal and Child Health Hospital Affiliated to Anhui Medical University,Hefei 230000,China)

机构地区：[1]安徽医科大学附属妇幼保健院妇产科,合肥230000

出　　处：《临床与病理杂志》2022年第2期387-393,共7页Journal of Clinical and Pathological Research

基　　金：安徽省科技创新项目(201707d08050003)。

摘　　要：目的:探讨新生儿窒息的相关临床风险因素,为预防新生儿窒息提供依据。方法:回顾分析2018年1月至2019年12月在安徽医科大学附属妇幼保健院出生的单胎活产新生儿及其母亲的临床资料,将发生窒息的新生儿作为观察组,并按照1:2比例抽取患儿母亲相邻住院号产妇分娩的非窒息新生儿作为对照组。比较2组新生儿及母亲的临床资料,分析影响新生儿窒息的相关临床风险因素。采用t检验、χ^(2)检验及二分类logistic回归分析对数据进行分析。结果:2018年1月至2019年12月我院新生儿窒息总体发生率为0.85%(246/29000)。两组新生儿母亲合并妊娠期高血压疾病、妊娠期肝内胆汁淤积症、产时发热、胎儿窘迫、羊水异常、胎盘异常、初产妇、产前计划分娩、剖宫产、产钳助产、第二产程延长、脐带异常、早产之间比较差异均有统计学意义(均P<0.05)。多因素logistic回归分析结果显示两组妊娠期肝内胆汁淤积症、胎位异常、产时发热、羊水异常、脐带异常、胎盘异常、早产、胎儿窘迫为新生儿窒息的相关临床风险因素。结论:妊娠期肝内胆汁淤积症、胎位异常、产时发热、羊水异常、脐带异常、胎盘异常、早产、胎儿窘迫为新生儿窒息的相关临床风险因素,应加强此类高危人群的管理,从而降低新生儿窒息的发生率。Objective:To explore clinical risk factors of neonatal asphyxia and to provide evidence for prevention of neonatal asphyxia.Methods:Clinical data of singleton live births and their mothers in the Maternal and Child Health Hospital of Anhui Medical University from January 2018 to December 2019 were retrospectively analyzed.The newborns with asphyxia were taken as an observation group.According to the proportion of 1:2,non-asphyxiated newborns delivered by mothers with adjacent hospitalization numbers were selected as a control group.The clinical data of newborns and mothers of the 2 groups were compared,and the related clinical risk factors of neonatal asphyxia were analyzed.The data were analyzed by t-test,χ^(2) test and binomial logistic regression analysis and multivariate logistic regression analysis.Results:The incidence of neonatal asphyxia in our hospital was 0.85%(246/29000).There were significant differences in hypertensive disorder of pregnancy,intrahepatic cholestasis of pregnancy,fever during delivery,fetal distress,abnormal amniotic fluid,placental abnormality,parturient,prenatal planned delivery,cesarean section,forceps delivery,prolonged second stage of labor,abnormal umbilical cord,and preterm delivery of mothers between the 2 groups(P<0.05).Multivariate logistic regression analysis showed that intrahepatic cholestasis of pregnancy,abnormal fetal position,fever during delivery,abnormal amniotic fluid,abnormal umbilical cord,placental abnormality,preterm delivery,and fetal distress were relevant clinical risk factors of neonatal asphyxia.Conclusion:Intrahepatic cholestasis of pregnancy,abnormal fetal position,fever during delivery,abnormal amniotic fluid,abnormal umbilical cord,placental abnormality,premature delivery,and fetal distress are the relevant clinical risk factors of neonatal asphyxia.Management of high risk groups should be strengthened to reduce the incidence of neonatal asphyxia.

关 键 词：新生儿窒息 早产 风险因素 

分 类 号：R722.12[医药卫生—儿科]