小剂量雌激素对围绝经期失眠患者睡眠状况及E2、FSH水平的影响  

Effects of Low Dose Estrogen on Sleep Status,E2 and FSH Levels in Patients with Perimenopausal Insomnia

作　　者：张清 ZHANG Qing(Ninghua General Hospital,Ninghua 365400,China)

机构地区：[1]宁化县总医院,宁化365400

出　　处：《世界睡眠医学杂志》2021年第12期2112-2114,共3页World Journal of Sleep Medicine

摘　　要：目的:探讨小剂量雌激素对围绝经期失眠患者睡眠状况及E_(2)、FSH水平的影响。方法:选取2019年1月至2020年12月宁化县总医院妇产科收治的围绝经期失眠患者99例作为研究对象,按照随机数字表法分为观察组和对照组,其中观察组49例,对照组50例。对照组给予常规治疗,观察组在对照组基础上,服用戊酸雌二醇片,2组均连续28 d的治疗,采用更年期症状Kupperman测评量表比较2组患者治疗前后变化,采用抽血检测的方法测定治疗前后性激素的变化,采用失眠严重程度指数量表(ISI)及匹兹堡睡眠质量指数(PSQI)量表比较2组患者睡眠改善状况。结果:治疗前,2组Kupperman评分比较,差异无统计学意义(P>0.05),治疗后,2组Kupperman评分各项指标均显著下降,2组患者ISI、PSQI评分显著降低,差异有统计学意义(均P<0.05)。结论:小剂量雌激素治疗能有效改善围绝经期失眠患者的性激素分泌情况和睡眠状况,提高患者睡眠质量,有效改善患者更年期症状,值得临床推广使用。Objective:To investigate the effects of low dose estrogen on sleep status,E_(2) and FSH levels in patients with perimenopausal insomnia.Methods:A total of 99 patients with perimenopausal insomnia admitted to the Department of Obstetrics and Gynecology of Ninghua General Hospital from January 2019 to December 2020 were selected as the research objects,and were divided into observation group and control group according to the random number table method,including 49 cases in the observation group and 50 cases in the control group.The control group was given conventional treatment,and the observation group was given estradiol valerate tablets on the basis of the control group.Both groups were treated for 28 consecutive days.The Kupperman scale of menopausal symptoms was used to compare the changes between two groups before and after treatment,and the changes of sex hormones before and after treatment were measured by blood sampling.Insomnia Severity Index Scale(ISI)and Pittsburgh Sleep Quality Index(PSQI)were used to compare the sleep improvement of 2 groups.Results:Before treatment,there was no statistically significant difference in Kupperman score between the two groups,but after treatment,all indexes of Kupperman score in the two groups decreased significantly,with statistically significant difference between the two groups(P<0.05).After treatment,ISI and PSQI scores between 2 groups were significantly decreased,with statistical significance(Ps<0.05).Conclusion:Low-dose estrogen therapy can effectively improve the sex hormone secretion and sleep status of patients with perimenopausal insomnia,improve the sleep quality of patients,effectively improve the menopausal symptoms of patients,which is worthy of clinical promotion.

关 键 词：围绝经期 失眠 雌激素 睡眠状况 性激素 

分 类 号：R256.23[医药卫生—中医内科学] R338.63[医药卫生—中医学]