低热量饮食干预与有氧运动干预对早期2型糖尿病肥胖患者胰岛素水平及人体成分的影响  

Effects of low-calorie diet intervention and aerobic exercise intervention on insulin levels and body composition in obese patients with type 2 diabetes

作　　者：司梅[1] 王惠琴[1] 黄云波 Si Mei;Wang Huiqin;Huang Yunbo(Department of Endocrinology,Xuanwu Hospital,Capital Medical University,Beijing 100053,China)

机构地区：[1]首都医科大学宣武医院内分泌科,北京100053

出　　处：《中国实用护理杂志》2022年第3期229-234,共6页Chinese Journal of Practical Nursing

基　　金：北京市自然科学基金(7120150)。

摘　　要：目的探讨低热量饮食干预与有氧运动干预对早期2型糖尿病肥胖患者胰岛素水平与人体成分的影响,为制订此类患者的干预措施提供理论依据。方法选取2016年7月至2019年7月于首都医科大学宣武医院内分泌科诊治的300例2型糖尿病肥胖患者作为研究对象,按照随机数字表法分为对照组与观察组各150例,对照组予以低热量饮食干预,观察组予以低热量饮食干预与集中有氧运动干预。对2组患者的空腹血糖、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、BMI、体脂百分比、体质量、三酰甘油、总胆固醇、HDL-C、LDL-C进行观察及评估。结果干预4周后,观察组FBG、FINS、HOMA-IR、BMI、体脂百分比、体质量、三酰甘油、总胆固醇、HDL-C、LDL-C分别为(6.15±0.92)mmol/L、(14.12±1.11)mU/L、2.67±0.32、(25.01±1.75)kg/m^(2)、(27.45±1.92)%、(70.01±3.56)kg、(3.01±0.30)mmol/L、(5.25±0.88)mmol/L、(2.25±0.42)mmol/L、(3.15±0.41)mmol/L,对照组分别为(8.18±1.28)mmol/L、(16.78±1.85)mU/L、3.78±0.78、(27.36±2.45)kg/m^(2)、(29.78±2.39)%、(72.98±5.62)kg、(3.49±0.52)mmol/L、(6.23±1.08)mmol/L、(1.88±0.30)mmol/L、(3.98±0.89)mmol/L,差异有统计学意义(t值为5.47~16.13,均P<0.05)。干预8周后,观察组FBG、FINS、HOMA-IR、BMI、体脂百分比、体质量、三酰甘油、总胆固醇、HDL-C、LDL-C分别为(5.06±0.45)mmol/L、(12.78±0.69)mU/L、2.01±0.12、(23.25±1.18)kg/m^(2)、(25.05±1.19)%、(66.02±2.45)kg、(2.21±0.12)mmol/L、(4.03±0.41)mmol/L、(3.08±0.72)mmol/L、(2.65±0.15)mmol/L,对照组分别为(6.07±0.88)mmol/L、(14.09±1.05)mU/L、2.95±0.45、(26.98±2.08)kg/m^(2)、(27.18±2.06)%、(70.98±4.02)kg、(2.98±0.28)mmol/L、(5.16±0.71)mmol/L、(2.41±0.51)mmol/L、(3.29±0.39)mmol/L,差异有统计学意义(t值为5.47~30.96,均P<0.05)。结论低热量饮食干预联合集中有氧运动干预更有利于改善患者的血糖、血脂水平,以及减轻体质量。Objective To explore the effects of low-calorie diet intervention and aerobic exercise intervention on insulin levels and body composition in obese patients with type 2 diabetes.Methods A total of 300 obese patients with early type 2 diabetes who were diagnosed and treated in the Department of Endocrinology,Xuanwu Hospital of Capital Medical University from July 2016 to July 2019 were selected as the research objects.According to the random sampling method,they were divided into a control group and an observation group with 150 cases each.Calorie diet intervention was given to control group,while the observation group was given low-calorie diet intervention and concentrated aerobic exercise intervention.Observation and evaluation of fasting blood glucose(FBG),fasting insulin(FINS),homeostasis model assessment of insulin resistance(HOMA-IR),body mass index(BMI),body fat percentage,body weight,triacylglycerol(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C)were conducted.Results After 4 weeks of intervention,FBG,FINS,HOMA-IR,BMI,body fat percentage,body mass,TG,TC,HDL-C,LDL-C indicators of the observation group were(6.15±0.92)mmol/L and(14.12±1.11)mU/L,2.67±0.32,(25.01±1.75)kg/m^(2),(27.45±1.92)%,(70.01±3.56)kg,(3.01±0.30)mmol/L,(5.25±0.88)mmol/L,(2.25±0.42)mmol/L,(3.15±0.41)mmol/L.The control group were(8.18±1.28)mmol/L,(16.78±1.85)mU/L,3.78±0.78,(27.36±2.45)kg/m^(2),(29.78±2.39)%,(72.98±5.62)kg,(3.49±0.52)mmol/L,(6.23±1.08)mmol/L,(1.88±0.30)mmol/L,(3.98±0.89)mmol/L.The difference between the two groups was statistically significant(t values were 5.47-16.13,all P<0.05).After 8 weeks of intervention,FBG,FINS,HOMA-IR,BMI,body fat percentage,body mass,TG,TC,HDL-C,LDL-C indicators of the observation were(5.06±0.45)mmol/L,(12.78±0.69)mU/L,2.01±0.12,(23.25±1.18)kg/m^(2),(25.05±1.19)%,(66.02±2.45)kg,(2.21±0.12)mmol/L,(4.03±0.41)mmol/L,(3.08±0.72)mmol/L,(2.65±0.15)mmol/L,while in the control group were(6.07±0.88)mmol/L,(14.09±1

关 键 词：低热量饮食干预 有氧运动干预 糖尿病 2型 肥胖 胰岛素 人体成分 

分 类 号：R587.1[医药卫生—内分泌]