辣木叶降脂颗粒对高脂血症小鼠降脂作用探析  

Experimental Study on The Lipid Lowering Effect of Capsicum Leaf Lipid Reducing Granule on Hyperesteremia Mice

作　　者：陈鑫 王云 张永萍 陈琴 Chen Xin;Wang Yun;Zhang Yongping;Chen Qin(Guizhou Univeisity of Traditional Chinese Medicine,Guiyang 550025,China;Guizhou Province Traditional Chinese Medicine Ethnic Medicine Processing and Preparation Engineering Technology Research Center,Guiyang 550025,China)

机构地区：[1]贵州中医药大学,贵州贵阳550025 [2]贵州省中药民族药炮制与制剂工程技术研究中心,贵州贵阳550025

出　　处：《亚太传统医药》2022年第2期16-19,共4页Asia-Pacific Traditional Medicine

基　　金：贵州省研究生教育创新计划(黔教合YJSCXJH[2018]057);国家苗药工程技术研究中心研究项目(2014FU125Q09);贵州省高层次创新型人才“百层次”人才培养项目(黔科合平台人才[2015]4030);贵州省药物新剂型新工艺科技创新人才团队建设项目(黔科合平台人才[2017]5655);贵州省国内一流建设学科建设项目(中药学)(GNYL[2017]008号)。

摘　　要：目的:探讨辣木叶降脂颗粒对高脂血症小鼠的降脂作用。方法:采用腹腔注射75%蛋黄乳和喂养高脂饲料分别复制急性和食饵性高脂血症模型,采用ELISA法观察正常组、模型组、辛伐他汀组(20mg/kg)及辣木叶降脂颗粒组高、中、低剂量组(19.2、9.6、4.8g/kg)小鼠的血脂水平,即血清中总胆固醇(TC)、甘油三脂(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)的表达。结果:将蛋黄乳或高脂饲料造模后,模型组小鼠与空白对照组相比,蛋黄乳造模后模型组小鼠血清中TG、TC、LDL-C水平升高和HDL-C水平的降低具有统计学意义(P<0.05);辣木叶降脂颗粒高剂量组小鼠血清HDL-C水平有一定程度升高(P<0.05),但TG、TC、LDL-C水平均无明显变化(P>0.05);辣木叶降脂颗粒高剂量组、中剂量组蛋黄乳致急性高脂血症模型小鼠血清TG水平有一定程度降低(P<0.05),但TC、LDL-C、HDL-C水平无明显变化(P>0.05);辣木叶降脂颗粒高剂量组食饵性高脂血症模型小鼠血清TG、TC、LDL-C水平有一定程度降低(P<0.05),中剂量组TG、LDL-C水平有一定程度降低(P<0.05)。结论:辣木叶降脂颗粒对高脂血症小鼠的血脂水平具有一定的改善作用,该研究为小鼠高脂血症的治疗提供了新的食疗方法。Objective:To investigate the lipid lowering effect of Capsicum leaflipid reducing granule in hyperlipidemia mice.Methods:The model of acute hyperlipidemia and predatory hyperlipidemia mice were established with 75%egg yolk milk and high fat diet.The levels of blood lipid in normal group,model group,simvastatin group(20 mg/kg),Capsicum leaflipid reducing granule group(19.2,9.6,4.8 g/kg)were observed by ELISA.That is,the expression of total cholesterol(TC),triglyceride(TG),low density lipoprotein(LDL-C),high density lipoprotein(HDL-C)in serum.Results:Compared with the blank control group,the serum levels of TG,TC,LDL-C and HDL-C in model group were significantly increased after egg yolk milk or high-fat diet modeling(P<0.05);High dose group of the Capsicum leaflipid reducing granule significantly increased serum HDL-C level of normal mice(P<0.05),had no significant effects on TG,TC and LDL-C(P>0.05);the Capsicum leaflipid reducing granule in high-dose and medium-dose groups could significantly reduce serum TG level of egg yolk milk induced acute hyperlipidemia model mice(P<0.05),and had no significant effect on TC,LDL-C and HDL-C(P>0.05);The high dose group of the Capsicum leaflipid reducing granule could reduce the serum levels of TG,TC and LDL-C in the model mice with bait hyperlipidemia(P<0.05),the levels of TG and LDL-C in medium dose group were significantly decreased(P<0.05).Conclusion:The Capsicum leaf lipid reducing granule can improve the blood lipid level of hyperlipidemia mice to a certain extent,and provide a new dietary therapy for the occurrence and development of hyperlipidemia in mice.

关 键 词：辣木叶降脂颗粒 高脂血症 血脂水平 降脂作用 

分 类 号：R285.5[医药卫生—中药学]