Value of urine IL-8, NGAL and KIM-1 for the early diagnosis of acute kidney injury in patients with ureteroscopic lithotripsy related urosepsis  

作　　者：Dan Tan Liang Zhao Wei Peng Fang-Hao Wu Guo-Bin Zhang Bo Yang Wen-Qian Huo 

机构地区：[1]Department of Urology,The General Hospital of Chongqing Steel Company,Chongqing,400081,China

出　　处：《Chinese Journal of Traumatology》2022年第1期27-31,共5页中华创伤杂志（英文版）

基　　金：This article was sponsored by Medical Research Foundation of Chongqing,China(2019MSXM034).

摘　　要：Purpose::To investigate the clinical value of urine interleukin-18(IL-8),neutrophil gelatinase-associated lipocalin(NGAL)and kidney injury molecule-1(KIM-1)for the early diagnosis of acute kidney injury(AKI)in patients with ureteroscopic lithotripsy(URL)related urosepsis.Methods::A retrospective study was carried out in 157 patients with urosepsis after URL.The patients were divided into AKI group and non-AKI group according to the Kidigo guideline and urine IL-8,NGAL and KIM-1 levels were detected by enzyme-linked immunosorbent assay at 0,4,12,24 and 48 h after the surgery.Receiver operating characteristic curve(ROC)was used to evaluate the diagnostic value of these three biomarkers for postoperative AKI.Results::The level of urine IL-8,NGAL and KIM-1 in AKI group was significantly higher than that in non-AKI group at 4,12,24 and 48 h(p<0.01).The ROC analysis showed the combined detection of urine IL-8,NGAL and KIM-1 at 12 h had a larger area under curve(AUC)than a single marker(0.997,95%CI:0.991-0.998),and the sensitivity and specificity were 98.2%and 96.7%,respectively.Pearson correlation analysis showed that the levels of urine NGAL at 4,12,24 and 48 h in AKI patients were positively correlated with the levels of urine KIM-1 and IL-18(p<0.01).Conclusion::AKI could be quickly recognized by the elevated level of urine IL-8,NGAL and KIM-1 in patients with URL-related urosepsis.Combined detection of the three urine biomarkers at 12 h after surgery had a better diagnostic performance,which may be an important reference for the early diagnosis of AKI.

关 键 词：UROSEPSIS Ureteroscopic lithotripsy Acute kidney injury Early diagnosis lnterleukin-18 Neutrophil gelatinase-associated lipocalin Kidney injury molecule-1 

分 类 号：R699[医药卫生—泌尿科学]