ATP-P2X7R轴在炎症性疾病中的作用  

Role of ATP-P2X7R axis in inflammatory diseases

作　　者：颜诗怡 陈诗垚 关飞[1] 雷家慧[1] YAN Shi-yi;CHEN Shi-yao;GUAN Fei;LEI Jia-hui(Department of Pathogenic Biology,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,Hubei Province,China)

机构地区：[1]华中科技大学同济医学院病原生物学系,湖北武汉430030

出　　处：《热带病与寄生虫学》2022年第1期50-56,60,共8页Journal of Tropical Diseases and Parasitology

基　　金：国家自然科学基金项目(81772220);湖北省大学生创新训练项目(S202110487337)。

摘　　要：三磷酸腺苷(adenosine triphosphate,ATP)除了作为供能物质之外,还可以通过与细胞表面的嘌呤受体P2X7(purinergic receptor 2X7,P2X7R)结合,激活下游相关信号通路,引起靶细胞产生特异性生物学效应。P2X7R在很多免疫细胞中广泛表达,如单核细胞、巨噬细胞、淋巴细胞、嗜酸性粒细胞等,ATP介导的P2X7R通路在炎症性疾病中发挥重要作用。本文就P2X7R所涉及的相关分子的基本概念、发现过程、主要来源及生理病理功能,以及ATPP2X7R信号通路及其在消化系统、呼吸系统、神经系统、免疫系统等常见炎症性疾病中的作用进行综述。In addition to being an energy source, adenosine triphosphate(ATP) can also bind to purinergic receptor 2X7(P2X7R) on the cell surface to activate downstream related signaling pathways and initiate various pathophysiological reactions. P2X7R is widely expressed on many immune cells, such as macrophages, monocytes, lymphocytes and eosinophils, etc. ATP-mediated P2X7R pathways can play important roles in inflammatory diseases. This paper reviewed the basic concepts, discovery history, main sources and physiological and pathological functions of related molecules involved in P2X7R, and the role of ATP-P2X7R signaling pathway in inflammatory diseases of digestive system, respiratory system, nervous system and immune system.

关 键 词：三磷酸腺苷 P2X7受体 炎症性疾病 信号通路 

分 类 号：R392[医药卫生—免疫学]