甲状腺全切除术与次全切除术治疗双侧结节性甲状腺肿的疗效对比  

Comparison of the efficacy of total thyroidectomy and subtotal thyroidectomy in the treatment of bilateral nodular goiter

作　　者：于振强 YU Zhen-qiang(Faku Central Hospital,Shenyang 110499,China)

机构地区：[1]辽宁省沈阳市法库县中心医院,110499

出　　处：《中国现代药物应用》2022年第4期62-64,共3页Chinese Journal of Modern Drug Application

摘　　要：目的探讨甲状腺全切除术与次全切除术治疗双侧结节性甲状腺肿的疗效。方法80例双侧结节性甲状腺肿患者,随机分为观察组和对照组,每组40例。对照组采用常规甲状腺全切除术进行治疗,观察组采用甲状腺次全切除术进行治疗。对比两组患者的临床相关指标(手术时间、住院时间、术中出血量以及术后疼痛评分)以及治疗后血清相关因子[血管内皮生长因子(VEGF),胰岛素样生长因子-Ⅰ(IGF-Ⅰ)以及转化生长因子-β1(TGF-β1)]水平。结果观察组患者手术时间(54.23±2.57)min以及住院时间(7.21±2.34)d短于对照组的(64.24±3.14)min、(9.22±2.39)d,术中出血量(68.23±2.64)ml少于对照组的(85.44±2.37)ml,术后疼痛程度评分(3.24±1.02)分低于对照组的(6.58±2.00)分,差异有统计学意义(P<0.05)。治疗后,观察组患者VEGF(32.12±2.15)pg/ml以及IGF-Ⅰ(25.12±1.28)ng/ml高于对照组的(22.03±2.03)pg/ml、(19.24±1.21)ng/ml,TGF-β1(284.23±10.23)pg/ml低于对照组的(362.12±12.03)pg/ml,差异有统计学意义(P<0.05)。结论临床采用甲状腺次全切除术治疗双侧结节性甲状腺肿患者,出血量较少,缓解疼痛,促进恢复,可以改善血清因子表达,防止复发。Objective To discuss the efficacy of total thyroidectomy and subtotal thyroidectomy in the treatment of bilateral nodular goiter.Methods A total of 80 patients with bilateral nodular goiter were randomly divided into observation group and control group,with 40 cases in each group.The control group was treated with conventional total thyroidectomy,and the observation group was treated with subtotal thyroidectomy.Both groups were compared in terms of clinical related indicators(operation time,hospitalization time,intraoperative blood loss and postoperative pain score),serum related factors[vascular endothelial growth factor(VEGF),insulin-like growth factor-Ⅰ(IGF-Ⅰ)and transforming growth factor-β1(TGF-β1)]levels after treatment.Results The operation time(54.23±2.57)min and hospitalization time(7.21±2.34)d of the observation group were shorter than(64.24±3.14)min and(9.22±2.39)d of the control group,and the intraoperative blood loss(68.23±2.64)ml was less than(85.44±2.37)ml of the control group,and the postoperative pain score(3.24±1.02)points was lower than(6.58±2.00)points of the control group.All the differences were statistically significant(P<0.05).After treatment,the VEGF(32.12±2.15)pg/ml and IGF-Ⅰ(25.12±1.28)ng/ml in the observation group were higher than(22.03±2.03)pg/ml and(19.24±1.21)ng/ml in the control group,and the TGF-β1(284.23±10.23)pg/ml was lower than(362.12±12.03)pg/ml in the control group.All the differences were statistically significant(P<0.05).Conclusion Clinical subtotal thyroidectomy for patients with bilateral nodular goiter can reduce clinical bleeding,relieve pain,promote recovery,improve the expression of serum factors and prevent recurrence.

关 键 词：甲状腺全切除术 甲状腺次全切除术 双侧结节性甲状腺肿 

分 类 号：R653[医药卫生—外科学]