更昔洛韦治疗小儿EB病毒感染的效果观察  

Observation on the effect of ganciclovir in the treatment of EB virus infection in children

作　　者：曲晓霞 QU Xiao-xia(Department of Pediatrics,Donggang Hospital of Traditional Chinese Medicine,Dandong 118300,China)

机构地区：[1]东港市中医院儿科,118300

出　　处：《中国现代药物应用》2022年第4期203-205,共3页Chinese Journal of Modern Drug Application

摘　　要：目的分析小儿EB病毒感染的特点,评价采用更昔洛韦治疗的效果。方法120例小儿EB病毒感染患儿,随机分为对照组和观察组,每组60例。对照组患儿采取重组人干扰素α1b治疗,观察组患儿在对照组基础上辅助更昔洛韦治疗。比较两组患儿临床疗效、不良反应发生情况、临床症状体征恢复时间。结果观察组患儿总有效率95.00%高于对照组的70.00%,差异具有统计学意义(P<0.05);两组患儿不良反应发生率比较差异无统计学意义(P>0.05)。观察组患儿退热时间、颈淋巴结肿大消退时间、咽痛消退时间、扁桃体肿大消退时间、肝脾肿大消退时间分别为(2.80±0.50)、(1.50±0.50)、(3.05±0.80)、(5.10±0.80)、(4.20±1.05)d,均短于对照组的(4.50±0.80)、(1.90±0.50)、(4.50±0.80)、(7.50±1.20)、(6.20±1.20)d,差异具有统计学意义(P<0.05)。结论辅助更昔洛韦治疗小儿EB病毒感染具有安全性、有效性价值,可以加速患儿症状体征恢复。Objective To analyze the characteristics of EB virus infection in children,and evaluate the effect of ganciclovir treatment.Methods A total of 120 patients with EB virus infection were randomly divided into control group and observation group,with 60 cases in each group.Children in the control group were treated with recombinant human interferonα1b,and children in the observation group were treated with ganciclovir on the basis of the control group.The clinical efficacy,occurrence of adverse reactions,and recovery time of clinical symptoms and signs were compared between the two groups.Results The total effective rate 95.00% in the observation group was higher than 70.00% in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).The time of fever reduction,regression time of cervical lymphadenopathy,sore throat,tonsil enlargement,and hepatosplenomegaly in the observation group were(2.80±0.50),(1.50±0.50),(3.05±0.80),(5.10±0.80),and(4.20±1.05)d,which were shorter than(4.50±0.80),(1.90±0.50),(4.50±0.80),(7.50±1.20),and(6.20±1.20)d in the control group,and the difference was statistically significant(P<0.05).Conclusion Adjuvant ganciclovir in the treatment of EB virus infection in children is safe and effective,and can accelerate the recovery of symptoms and signs in children.

关 键 词：更昔洛韦 小儿EB病毒感染 治疗效果 不良反应 症状体征消退时间 

分 类 号：R725.1[医药卫生—儿科]