加减半夏泻心汤治疗2型糖尿病伴抑郁症状患者的临床疗效及炎症因子水平的变化  

Clinical efficacy of the Banxia Xiexin decoction on type 2 diabetes with depression and the changes of inflammatory factors

作　　者：陆娟 陆艳[2] LU Juan;LU Yan

机构地区：[1]泰州市中医院,江苏泰州225300 [2]南京医科大学第二附属医院,江苏南京210000

出　　处：《中医临床研究》2021年第30期78-80,共3页Clinical Journal Of Chinese Medicine

摘　　要：目的:观察加减半夏泻心汤治疗2型糖尿病伴抑郁症状患者的临床疗效及炎症因子水平的变化。方法:选取60例2型糖尿病伴抑郁症状患者,采用随机数字表法分为两组,分别是中药组和对照组,各30例患者,因两组在治疗过程中各有2例脱落,实际每组各28例患者完成研究,对照组给予常规降糖治疗,包括药物、运动、饮食结构调整、健康宣教等,中药组在对照组基础上给予半夏泻心汤,共治疗4周,检测治疗前后患者糖化血红蛋白、汉密尔顿抑郁量表(Hamilton Depression Scale,HAMD)评分、血液中炎症因子白细胞介素-6(Interleukin-6,IL-6)和C反应蛋白(C-reactive Protein,CRP)的水平。结果:治疗后两组的糖化血红蛋白均明显改善,中药组降低率优于对照组,差异有统计学意义(P<0.05),提示中药组在降血糖方面优于对照组;治疗后两组患者HAMD评分均明显降低,中药组较对照组评分降低更明显,差异有统计学意义(P<0.05),提示经过4周治疗中药在改善抑郁方面明显优于对照组;治疗后两组患者IL-6和CRP水平均明显降低,中药组较对照组降低更明显,差异有统计学意义(P<0.05),提示中药组的治疗方案减少炎症因子水平优于对照组。结论:加减半夏泻心汤治疗2型糖尿病伴抑郁症状患者较常规治疗的疗效更优,可以改善患者的主观情绪感受,并能有效降低糖化血红蛋白及相关炎症因子指标。Objective:To observe the clinical efficacy of the Banxia Xiexin decoction(半夏泻心汤)in the treatment of type 2 diabetes with depression and the changes of inflammatory factors.Methods:60 cases were randomly divided into two groups,the traditional Chinese medicine group and the control group,with 30 patients in each group.Because there were 2 cases of falling off in each group,28 patients in each group completed the study.The control group was given routine hypoglycemic treatment,including drugs,exercise,diet adjustment,health education,etc.The traditional Chinese medicine group was treated with the Banxia Xiexin decoction more for 4 weeks.The levels of glycosylated hemoglobin,HAMD,IL-6 and CRP were measured before and after treatment.Results:After treatment,the glycosylated hemoglobin in the two groups were significantly ameliorat,the reduction in the traditional Chinese medicine group was better than the control group,the difference was statistically significant(P<0.05),suggesting that the traditional Chinese medicine group was better than the control group in reducing blood sugar;after treatment,the HAMD scores in the two groups were significantly reduced,and in the traditional Chinese medicine group was significantly lower than the control group,the difference was statistically significant(P<0.05),indicating that after 4 weeks of treatment,the blood sugar level in the traditional Chinese medicine group was significantly lower than the control group.After treatment,the levels of IL-6 and CRP in the two groups were significantly lower than those before treatment,and the decrease in the traditional Chinese medicine group was more significant than that in the control group,the difference was statistically significant(P<0.05),suggesting that the treatment scheme in the traditional Chinese medicine group is better than the control group in reducing the level of inflammatory factors.Conclusion:The Banxia Xiexin decoction is more effective than conventional treatment in the treatment of type 2 diabetes with depr

关 键 词：半夏泻心汤 2型糖尿病 抑郁症状 糖化血红蛋白 汉密尔顿抑郁量表 白细胞介素-6 C反应蛋白 

分 类 号：R587.1[医药卫生—内分泌]