输注悬浮红细胞后中性粒细胞与淋巴细胞比值及降钙素原对重症肺炎诊断意义的影响  

Changes of NLRand PCT Levels in the Influence of the Diagnostic Value on the Severe Pneumonia after Transfusion of Suspended Red Blood Cells

作　　者：赵子贤 林锦锋 李娟红 谭柏松 Zhao Zixian(Department of Blood Transfusion,Affiliated Xinhui Hospital,Southern Medical University,Jiangmen Guangdong 529100)

机构地区：[1]南方医科大学附属新会医院输血科,广东江门529100 [2]南方医科大学附属新会医院重症医学科,广东江门529100 [3]南方医科大学附属新会医院检验科,广东江门529100

出　　处：《黑龙江医药》2022年第1期10-13,共4页Heilongjiang Medicine journal

基　　金：2020年江门市科学技术局科技计划项目(立项编码:2020YLH023)。

摘　　要：目的:探讨输注悬浮红细胞后中性粒细胞与淋巴细胞比值(NLR)及降钙素原(PCT)对重症肺炎(SP)诊断意义的影响。方法:收集2019年1月至2021年2月在我院重症医学科治疗的肺部感染患者共70例,按照输注悬浮红细胞(1单位或以上)分为输注悬浮红细胞前和输注悬浮红细胞后两组,另外选70名健康查体人为正常参照组。用五分类全自动血细胞分析仪测试三组血常规得出中性粒细胞计数(NEUT^(#))和淋巴细胞计数(LYM^(#)),两者相除得出中性粒细胞与淋巴细胞比值(NLR),用全自动干式荧光免疫分析仪检测血液中的降钙素原(PCT)。结果:输注悬浮红细胞前和输注悬浮红细胞后两组的NLR水平均大于正常参照组(P<0.001),PCT水平均大于正常参照组(P<0.001)。输注悬浮红细胞前和输注悬浮红细胞后两组的NLR和PCT水平之间差异没有统计学意义(P>0.05)。用直线相关性分析显示,输注悬浮红细胞后NLR和PCT两者之间的直线相关性较差(r=0.345,P<0.01)。在ROC曲线下,输注悬浮红细胞前NLR联合PCT诊断重症肺炎的敏感性为92.7%,特异性为42.9%,曲线下面积(AUC)为0.678,输注悬浮红细胞后NLR联合PCT诊断重症肺炎的敏感性为94.6%,特异性为50%,曲线下面积(AUC)为0.723。结论:输注悬浮红细胞前或后,NLR或PCT都可以作为预测重症肺炎发生的风险指标,两者联合检测能提高预测重症肺炎发生敏感性,但特异性均较低。输注悬浮红细胞后,NLR和PCT的水平差异没有统计学意义。Objective:To discuss the changes of NLR and PCT levels in the influence of the diagnostic value on the severe pneumonia After transfusion of suspended red blood cells.Methods:70 patients with severe pneumonia in the department of critical care in our hospital from January 2019 to February 2021 were collected and divided into the before transfusion of suspended red blood cells and after transfusion of suspended red blood cells,according to infuse 1 unit or more suspended red blood cells.Another 70 healthy people were chosen as the healthy control group.The NEUT^(#)and LYM^(#)levels were detected by Five classification automatic blood cell analyzer and the PCT levels was detected by Automatic dry fluorescent immunoassay analyzer.The result of NLR was got by dividing NEUT^(#)by LYM^(#).Results:Both the NLR and the PCT levels significantly increased in the before transfusion of suspended red blood cells and the post transfusion of suspended red blood cells,compared to the healthy control group(P<0.001).There was no statistic difference in the mean level of NLR and PCT between the before transfusion of suspended red blood cells and the post transfusion of suspended red blood cells.(P>0.05).There was no correlation between NLR and PCT in the before transfusion of suspended red blood cells and the post transfusion group by the correlation analysis(r=0.345,P<0.01).To detect in the diagnostic on the severe pneumonia,the ROC curve analysis show that it can detect NLR and PCT together in the before transfusion of suspended red blood cells,the sensitivity was 92.7%and the specificity was 42.9%.Under the ROC curve,the areas was 0.678.Anther,in the post transfusion of suspended red blood cells,the sensitivity was 94.6%and the specificity was 50%.Under the ROC curve,the areas was 0.723.Conclusion:The NLR or PCT can be used as risk indicators to predict the occurrence of severe pneumonia whether before or after transfusion of suspended red blood cells.If you combine detection of NLR and PCT,it can improve the sensitivity of pred

关 键 词：悬浮红细胞 中性粒细胞与淋巴细胞比值 降钙素原 重症肺炎 

分 类 号：R563.1[医药卫生—呼吸系统]