胆道菌群导致原发性肝内胆管结石形成机理的研究进展  

Research advances in the formation mechanism of primary intrahepatic stones caused by biliary flora

作　　者：任江平 邱锦飞 邹杨 蔡晓蓓[1] 徐承雷 李江[1] REN Jiangping;QIU Jinfei;ZOU Yang;CAI Xiaobei;XU Chenglei;LI Jiang(Department of Hepatobiliary Surgery,The First Affiliated Hospital of Kunming Medical University,Kunming 650032,China)

机构地区：[1]昆明医科大学第一附属医院肝胆外科,昆明650032

出　　处：《临床肝胆病杂志》2022年第2期477-482,共6页Journal of Clinical Hepatology

基　　金：云南省科技厅-高校联合基金项目(202001AC070604)。

摘　　要：原发性肝内胆管结石(PIS)是我国西南地区高发和难治性疾病,在初始治疗后,部分患者仍需要再次甚至多次手术。近年来有大量研究发现部分特异性菌群能在肝内胆管定植,导致胆道系统慢性感染及炎症。这些特异菌群可产生β-葡萄糖醛酸苷酶等代谢产物,在色素性结石的形成中起着重要作用,被称为“致石菌群”。本文对PIS发病机理中致石菌群的作用研究进展予以分析探讨,以期为PIS患者提供更多的治疗方式。Primary intrahepatic stones(PIS)is a refractory disease with a high incidence rate in southwest China,and some patients still require surgery again or even more times after initial treatment.Many studies in recent years have shown that some specific flora can colonize in the intrahepatic bile duct,leading to chronic infection and inflammation of the biliary system,and these specific types of flora,called“stone-causing flora”,can produce metabolites such asβ-glucuronidase and play an important role in the formation of pigmented stones.This article analyzes the role of stone-causing flora in the pathogenesis of PIS,so as to provide more treatment options for PIS patients.

关 键 词：原发性肝内胆管结石 胆道菌群 病理过程 

分 类 号：R657.42[医药卫生—外科学]