健脾利湿方对白兔骨筋膜室综合征早期肿胀的影响  

The Influence of Spleen-Activating and Dampness-Draining Formula on Early Swelling of Rabbit Osteofascial Compartment Syndrome

作　　者：张德生[1] ZHANG De-sheng(Third Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou,Henan,China,450008)

机构地区：[1]河南中医药大学第三附属医院,河南郑州450008

出　　处：《河南中医》2022年第4期547-552,共6页Henan Traditional Chinese Medicine

基　　金：河南省中医药科学研究专项课题项目(2019ZYZD01)。

摘　　要：目的:观察健脾利湿方对白兔骨筋膜室综合征早期肿胀的影响。方法:将健康白兔30只适应性喂养2 d后,按照随机数字表法分为空白组10只和模型组20只。模型组造模成功分为健脾利湿组和模型对照组,每组各10只。空白组不做灌胃处理,健脾利湿组给予健脾利湿方灌胃,模型对照组给予生理盐水灌胃。观察各组白兔造模前及造模后2 h、12 h、24 h、48 h、96 h、7 d下肢周径、组织内压、尿量、肌肉神经病理变化情况。结果:造模后各时间点,模型对照组下肢周径大于空白组;造模后2 h、12 h、24 h、48 h、96 h,健脾利湿组下肢周径大于空白组;造模后48 h、96 h、7 d,健脾利湿组下肢周径大于模型对照组,差异均有统计学意义(P<0.05)。造模后各时间点,健脾利湿组和模型对照组组织内压大于空白组;造模后96 h、7 d,健脾利湿组组织内压大于模型对照组,差异有统计学意义(P<0.05)。造模后2 h、12 h、24 h,健脾利湿组尿量少于空白组,差异有统计学意义(P<0.05);造模前、造模后12 h、48 h、96 h、7 d,健脾利湿组尿量与模型对照组比较,差异有统计学意义(P<0.05)。空白组骨骼肌纤维正常;模型对照组伤侧组织坏死,结构破坏,大量炎细胞浸润;健脾利湿组伤侧细胞肿胀破坏程度较轻,有炎细胞浸润。结论:将自拟健脾利湿方运用于白兔骨筋膜室综合征,可降低组织内压力,增加尿量,从而减轻下肢肿胀程度,改善局部病理损伤程度。Objective:To observe the influence of Spleen-Activating and Dampness-Draining Formula on early swelling of rabbit osteofascial compartment syndrome.Methods:After having been adaptively fed for 2 days,30 healthy white rabbits were randomly divided into the blank group with 10 rats and the model group with 20 rats respectively.The model group was then again successfully divided into the group of Spleen-Activating and Dampness-Draining Formula and the model control group,with 10 rats in each group.The blank group was not treated by gavage;the group of Spleen-Activating and Dampness-Draining Formula was treated with Spleen-Activating and Dampness-Draining Formula,and the model control group was given normal saline.The peripheral diameter of lower limbs,tissue internal pressure,urine volume and pathological changes of muscle and nerve of white rabbits in each group were observed before modeling and 2 h,12 h,24 h,48 h,96 h and 7 d after modeling.Results:At each time point after modeling,the peripheral diameter of lower limbs in the model control group was greater than that in the blank group.At 2 h,12 h,24 h,48 h and 96 h after modeling,the peripheral diameter of lower limbs in the group of Spleen-Activating and Dampness-Draining Formula was greater than that in the blank group.At 48 h,96 h and 7 d after modeling,the peripheral diameter of lower limbs in the group of Spleen-Activating and Dampness-Draining Formula was greater than that in model control group,and all the differences were statistically significant(P<0.05).At each time point after modeling,the tissue internal pressure in the group of Spleen-Activating and Dampness-Draining Formula and the model control group was both greater than that in the blank group;96 hours and 7 days after modeling,the tissue internal pressure in the group of Spleen-Activating and Dampness-Draining Formula was higher than that in the model control group,and all the differences were statistically significant(P<0.05).At 2 h,12 h and 24 h after modeling,the urine volume of the group of

关 键 词：骨筋膜室综合征 早期肿胀 健脾利湿方 白兔 

分 类 号：R285.5[医药卫生—中药学]