黄体酮新剂型及其制备方法研究进展  

Research progress on new dosage forms of progesterone and its preparation methods

作　　者：王玥 程艺 刘原兵 李静如 张慧 郑爱萍 WANG Yue;CHENG Yi;LIU Yuan-bing;LI Jing-ru;ZHANG Hui;ZHENG Ai-ping(School of Pharmacy,Xuzhou Medical University,Xuzhou 221000,China;Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences,Academy of Military Sciences,Beijing 100850,China;73101 Unit of the Chinese People's Liberation Army,Xuzhou 221000,China)

机构地区：[1]徐州医科大学药学院,江苏徐州221000 [2]军事科学院军事医学研究院毒物药物研究所,北京100850 [3]中国人民解放军73101部队,江苏徐州221000

出　　处：《药学学报》2022年第2期353-363,共11页Acta Pharmaceutica Sinica

基　　金：国家“重大新药创制”科技重大专项(2018ZX09721003-005-009);河北省重点研发计划项目(19272701D)。

摘　　要：黄体酮是目前临床上治疗、预防先兆流产和习惯性流产的一线药物。随着我国生育政策的逐渐放开,高龄产妇显著增加,市场对黄体酮的需求量及个性化要求不断提高。临床研究发现,黄体酮的适应症并不局限于妇科疾病,还可用于肾绞痛、创伤性脑损伤等疾病的治疗。现有黄体酮上市制剂有口服胶囊、肌肉注射剂和阴道凝胶剂等,但其已无法满足市场的需求及适应症的增多。开发新型制剂、开拓新的给药途径已成为黄体酮药物研究的方向之一。本文将黄体酮现有给药途径中的新剂型、给药新途径及其相关制备方法研究做一综述。Progesterone is currently the first-line drug for the treatment and prevention of threatened abortion and habitual abortion.With the gradual liberalization of China’s childbirth policy,the number of elderly parturients has increased significantly.As a result,the market demand for progesterone and the individual requirements have been continuously improved.Clinical studies have found that the indications of progesterone are not limited to gynecological diseases,but can also be used for the treatment of renal colic,traumatic brain injury and other diseases.Existing progesterone preparations include oral capsules,intramuscular injections,vaginal gels,etc.,but they can no longer meet the current market situation and the increase of indications.Improving existing preparations,developing new preparations,and opening up new routes of administration have become one of the directions of progesterone drug research.This article will review the research progress of new dosage forms in existing administration,new routes of administration and related preparation methods of progesterone.

关 键 词：黄体酮 临床适应症 药物新剂型 给药新途径 制备方法 

分 类 号：R943[医药卫生—药剂学]