蜘蛛香中的倍半萜和环烯醚萜类成分及其抗炎和抗流感病毒活性  

Sesquiterpenoids and iridoids from Valeriana jatamansi with anti-inflammatory and anti-influenza virus properties

作　　者：石道群 王云 饶凯瑞 蒋娜 刘丹[1] 李蓉涛[1] 李洪梅[1] SHI Dao-qun;WANG Yun;RAO Kai-rui;JIANG Na;LIU Dan;LI Rong-tao;LI Hong-mei(Faculty of Life Science and Technology,Kunming University of Science and Technology,Kunming 650500,China)

机构地区：[1]昆明理工大学生命科学与技术学院,云南昆明650500

出　　处：《药学学报》2022年第2期428-432,共5页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(32060106,31560103);云南省应用基础研究计划项目(2019FB025);昆明理工大学新型抗流感药物研发省创新团队(2019HC018)。

摘　　要：采用多种色谱技术从蜘蛛香根和根茎中分离得到3个倍半萜和9个环烯醚萜,并依据理化性质、NMR和MS数据鉴定了化合物的结构。其中,蜘蛛香酯G(1)是新的广藿香醇型倍半萜,化合物3为首次从缬草属植物中分离得到。化合物3和10可显著抑制脂多糖(LPS)诱导的小鼠巨噬细胞RAW 264.7中NO的释放,IC_(50)值分别为19.00和3.66μmol·L^(-1)。化合物4、6和12具有一定的抗流感病毒活性,IC_(50)值分别为51.75、51.40和102.08μmol·L^(-1)。Three sesquiterpenoids and nine iridoids were isolated from the roots and rhizomes of Valeriana jatamansi by various chromatographic methods.Their structures were identified by physicochemical properties,NMR and MS data.Among them,valeriananoid G(1)was a new patchoulol-type sesquiterpenoid,and compound 3 was isolated from the genus Valeriana for the first time.Compounds 3 and 10 exhibited significant inhibitory effects on nitric oxide production induced by lipopolysaccharide in RAW 264.7 macrophages,with IC_(50) values of19.00 and 3.66μmol·L^(-1),respectively.In addition,compounds 4,6 and 12 showed anti-influenza virus activity with IC_(50) values of 51.75,51.40 and 102.08μmol·L^(-1),respectively.

关 键 词：蜘蛛香 倍半萜 环烯醚萜 抗炎 抗流感病毒 

分 类 号：R284[医药卫生—中药学]