逐瘀汤加减灌肠辅助治疗强直性脊柱炎瘀血痹阻证70例临床观察  

Clinical observation of 70 cases of ankylosing spondylitis with obstruction due to blood stasis syndrome adjuvantly treated by modified Zhuyu Tang( 逐瘀汤) enema

作　　者：赵俊燕[1] ZHAO Junyan(Department One of Bone Disease,Henan Provincial Hos|)ital of TCM,Zhengzhou,Henan,450002,China)

机构地区：[1]河南省中医院骨病一科,河南郑州450002

出　　处：《甘肃中医药大学学报》2022年第1期56-60,共5页Journal of Gansu University of Chinese Medicine

基　　金：河南省科技厅科技攻关项目(162102310447)。

摘　　要：目的观察逐瘀汤加减灌肠辅助治疗强直性脊柱炎(AS)瘀血痹阻证的临床疗效,以及对血清炎症因子和免疫功能的影响。方法将140例AS瘀血痹阻证患者采用随机数字表法分为对照组和治疗组,各70例。对照组采用常规西医治疗,治疗组在对照组治疗方法的基础上给予逐瘀汤加减灌肠治疗,2组均连续治疗4周。4周后比较2组的临床疗效和不良反应发生率,以及治疗前后的巴氏强直性脊柱炎总和指数(BAS-G)评分、活动性指数(BASDAI)评分、中医症状积分,血清炎症因子[肿瘤坏死因子-α(TNF-α)、C-反应蛋白(CRP)、白细胞介素-6(IL-6)]和免疫球蛋白(Ig) A、IgG、IgM的含量。结果对照组总有效率为70.0%(49/70),治疗组为97.1%(68/70),2组比较差异有统计学意义(P <0.05);治疗后2组BAS-G评分、BASDAI评分、中医症状积分以及血清TNF-α、CRP、IL-6、IgA、IgG、IgM含量均明显降低,与同组治疗前比较差异有统计学意义(P<0.05或P<0.01),且治疗组降低更明显,与对照组治疗后比较差异均有统计学意义(P<0.05或P<0.01);对照组总不良反应发生率为27.1%(19/70),治疗组为21.3%(15/70),2组比较差异无统计学意义(P>0.05)。结论逐瘀汤加减灌肠辅助治疗AS瘀血痹阻证可有效改善患者的临床症状,降低血清炎症因子及免疫球蛋白含量,疗效显著,值得临床推广应用。Objective To observe the clinical efficacy of modified Zhuyu Tang(逐瘀汤)enema in adjuvant treatment of ankylosing spondylitis(AS)with obstruction due to blood stasis syndrome and its effects on serum inflammatory factors and immune function.Methods Totally 140 cases of AS with obstruction due to blood stasis syndrome were divided into control group and treatment group according to random number table method,with 70 cases in each group.The control group was given routine Western medicine treatment,on this basis,the treatment group was given modified Zhuyu Tang enema with consecutive 4 weeks of treatment.After 4 weeks of treatment for both groups,the clinical efficacy and incidence of adverse reactions occurrence,the bath ankylosing spondylitis patient global(BAS-G)score,the bath ankylosing spondylitis disease activity index(BASDAI),TCM symptom score,levels of serum inflammatory factors[tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)and interleukin-6(IL-6)and immunoglobulin(Ig)A,IgG,IgM]before and after treatment between the 2 groups were compared.Results The total effective rate was 70.0%(49/70)in the control group and 97.1%(68/70)in the treatment group,and the difference between the 2 groups was statistically significant(P<0.05).After treatment,the scores of BAS-G,BASDAI and TCM symptom in the 2 groups significantly decreased,along with the significant decrease of serum levels of TNF-α,CRP,IL-6,IgA,IgG and IgM,and the differences were statistically significant than those in the same group before treatment(P<0.05 or P<0.01),moreover,the decrease was more significant in the treatment group,and the differences were statistically significant than those in the control group after treatment(P<0.05 or P<0.01).The total incidence of adverse reactions was 27.1%(19/70)in the control group and 21.3%(15/70)in the treatment group,and there was no statistically significant difference between the 2 groups(P>0.05).Conclusion It can effectively alleviate the clinical symptoms of patients,and reduce the levels of ser

关 键 词：强直性脊柱炎 瘀血痹阻证 逐瘀汤加减 灌肠 炎症因子 免疫球蛋白 临床疗效 

分 类 号：R259.932.3[医药卫生—中西医结合]