宁夏枸杞子治疗肝脏疾病的作用机制  

Mechanisms of wolfberry in the treatment of liver diseases

作　　者：车招娣 周正群 肖佳 Zhaodi Che;Zhengqun Zhou;Jia Xiao(Clinical Medicine Research Institute,the First Affiliated Hospital of Jinan University,Guangzhou 510632,China;Institute of Traditional Chinese Medicine&Natural Products,College of Pharmacy,Jinan University,Guangzhou 510632,China)

机构地区：[1]暨南大学附属第一医院临床研究院,广州510632 [2]暨南大学药学院中药及天然药物研究所,广州510632

出　　处：《科学通报》2022年第4期351-363,共13页Chinese Science Bulletin

基　　金：国家自然科学基金(81970515)资助。

摘　　要：枸杞子作为药食同源的植物,具有滋补肝肾、益精明目等诸多药理作用,是中国传统的中草药和食品补品,但直到近年来其分子机制研究才被重视.枸杞子含有丰富的生物活性成分,如枸杞多糖、枸杞色素和枸杞亚精胺等组分,能够改善多种疾病的病症.研究表明,枸杞子具有显著的抗炎、抗氧化、抗凋亡、抗纤维化和抗肿瘤等作用.枸杞子性平味甘,对于大部分肝脏疾病具有显著的修复功能,并且在防治相关并发症等方面取得良好效果.但由于枸杞子的活性物质复杂多样,研究人员难以厘清发挥这些有益功效的主要单体和具体的分子机制,从而限制其在保健食品和药物方面的应用.本文总结了枸杞子提取物在肝病治疗中的作用和机制,梳理了现有枸杞子护肝研究的优势和不足,以期为肝脏疾病的研究提供新的给药方案,对促进枸杞子活性成分的药物开发进程提供参考和借鉴.The fruit of Lycium barbarum(the wolfberry or Goji berry)has been widely used as a drug and functional food in many traditional Chinese medicine literature.However,only in recent years has its specific health-promoting mechanism been investigated.Modern technology of pharmacology has identified a variety of bioactive ingredients from the Goji berry,such as polysaccharide,pigments,and lycibarbarspermidines,with properties of anti-inflammation,antioxidant,antiapoptosis,anti-fibrosis,and anti-tumor.Acute and chronic liver diseases represent a major world public health problem.The clinical curative rate for some liver diseases,such as chronic hepatitis B,cirrhosis,and liver cancer remains unsatisfactorily low.In the current review,we summarized the updated mechanisms of bioactive ingredients derived from the Goji berry in liver diseases,which may pave the way for their future clinical application.The hepatoprotective properties of Lycium barbarum polysaccharide(LBP)have been characterized in several liver disease models,including acute liver injury,liver failure,non-alcoholic liver disease,alcoholic liver disease,liver fibrosis,and liver cancer.However,delineating the active ingredient(s)from LBP in different types of liver diseases is a challenge.Wolfberry also contains the highest concentration of the antioxidant xanthophyll carotenoid zeaxanthin dipalmitate(ZD).ZD is a zeaxanthin diester formed from zeaxanthin(ZE)and palmitic acid.Inducing non-alcoholic in the transgenic HBV mice model reactivated HBV replication,while ZD administration reduced HBV DNA replication and serum HBsAg levels.The immediate hepatocyte membrane receptors of ZD during alcoholic liver injury have also be identified.Treating human adiposederived mesenchymal stem cells(hADMSC)with ZD before transplantation increased stem cell survival and improved the therapeutic outcome in acute liver disease/failure models.Betaine is a natural amino acid and one of the major constituents of Lycium barbarum.It is shown to play antioxidant and anti-inflammato

关 键 词：枸杞子 活性成分 肝脏疾病 护肝 

分 类 号：R259[医药卫生—中西医结合]