方便门诊糖尿病患者降糖药物知晓率的调查及其影响因素研究  

Awareness rate of hypoglycemic drugs and its influencing factors in the diabetic patients at convenient outpatient

作　　者：刘晨霄 胡兴娜 陈佳奇 赵云 陆宏虹 Liu Chenxiao;Hu Xingna;Chen Jiaqi;Zhao Yun;Lu Honghong(Department of Endocrinology,Affiliated Suzhou Hospital of Nanjing Medical University,Suzhou Municipal Hospital,Gusu School,Nanjing Medical University,Suzhou 215000,China)

机构地区：[1]南京医科大学姑苏学院,南京医科大学附属苏州医院,苏州市立医院内分泌科,苏州215000

出　　处：《中华糖尿病杂志》2022年第2期173-178,共6页CHINESE JOURNAL OF DIABETES MELLITUS

基　　金：苏州市科技项目(SYSD2017116)。

摘　　要：目的探讨在方便门诊配药的糖尿病患者对其所使用的降糖药物的知晓情况及其影响因素。方法选取2018年12月至2020年6月于南京医科大学附属苏州医院方便门诊和所属医联体的社区卫生服务中心就诊的糖尿病患者。记录患者的年龄、性别、文化程度、糖尿病家族史、是否独居、服用降糖药物种类数、服用药物总种类数、糖化血红蛋白(HbA1c)等基线资料,根据药物知晓情况分为完全知晓组、部分知晓组和完全不知晓组,由专职临床药师对患者进行药物教育,分别于教育12周及24周后再次收集各组患者药物知晓情况,并再次检测HbA1c。两组或3组间临床指标的比较采用t检验、方差分析、Kruskal-Wallis秩和检验或χ^(2)检验,采用多因素logistic回归分析法分析影响降糖药物知晓率的可能因素。结果共纳入1811例糖尿病患者,其中完全知晓组占29.26%(530/1811),部分知晓组占63.56%(1151/1811),完全不知晓组占7.18%(130/1811)。对患者进行药物教育12周后,完全知晓组人数比例增至52.90%(958/1811),部分知晓组比例减至42.08%(762/1811),完全不知晓组比例减至5.02%(91/1811)。药物教育24周后,完全知晓组人数比例为46.05%(834/1811),部分知晓组比例为50.80%(920/1811),完全不知晓组比例减至3.15%(57/1811)。药物教育前、药物教育12周及24周后3组间的HbA1c差异均有统计学意义(F值分别为48.21、16.22和8.03,均P<0.001)。多因素logistic回归分析结果显示,年龄(OR=0.98,95%CI 0.97~0.99,P<0.001)、性别(OR=0.70,95%CI 0.57~0.86,P=0.001)、文化程度(OR=1.94,95%CI 1.57~2.39,P<0.001)、独居(OR=0.48,95%CI 0.35~0.65,P<0.001)、有糖尿病家族史(OR=1.28,95%CI 1.04~1.57,P=0.020)、服用降糖药物种类数(OR=0.56,95%CI 0.49~0.65,P<0.001)、服用药物总种类数(OR=0.19,95%C 0.16~0.22,P<0.001)均影响患者降糖药物知晓情况。结论糖尿病患者降糖药物知晓率较低,经过药物教育后患者对药物的知晓程度Objective To investigate the awareness rate of hypoglycemic drugs in the diabetic patients at convenient outpatient services which dispense drugs,and to explore the factors affecting the awareness rate of hypoglycemic drugs.Methods Diabetic patients who visited the community health service centers of Affiliated Suzhou Hospital of Nanjing Medical University convenient outpatient service and its medical alliances from December 2018 to June 2020 were selected.Baseline data such as age,gender,education level,family history of diabetes,whether the patient lives alone,number of types of hypoglycemic drugs,total number of types of drugs taken,and glycated hemoglobin A1c(HbA1c)were recorded.The patients were divided into complete awareness group,partial awareness group and completely unknown group according to drug awareness.Full-time clinical pharmacists provided medications education for patients in each group.The participants were given with specialist medical education,and questionnaires were given again at 12 and 24 weeks to acquire the drug awareness,moreover the patients were rechecked HbA1c level.The comparison of clinical parameters in two or three groups was performed using t-test,analysis of variance,Kruskal-Wallis rank sum test orχ^(2) test,and multivariate logistics regression analysis was used to analyze the possible factors affecting the awareness of hypoglycemic drugs.Results A total of 1811 diabetic patients were enrolled,of whom 29.26%(530/1811)were fully aware,63.56%(1151/1811)were partially aware,and 7.18%(130/1811)were completely unaware.After medications education 12 weeks,the proportion of patients in the fully aware group increased to 52.90%(958/1811),the proportion of patients in the partially aware group decreased to 42.08%(762/1811),and the proportion of patients in the fully unaware group decreased to 5.02%(91/1811).After education intervention 24 weeks,the proportion of the patients with complete awareness was 46.05%(834/1811),the proportion of the partially aware group was 50.80%(920/1811),

关 键 词：糖尿病 降糖药物 知晓率 血糖控制 

分 类 号：R587.1[医药卫生—内分泌]