冠心病的遗传机制  

Genetics of coronary artery disease

作　　者：吴安东 刘建坤 赵雅 KHAN Abdul Haseeb 廖立勇 田小利[1] WU An Dong;LIU Jian Kun;ZHAO Ya;KHAN Abdul Haseeb;LIAO Li Yong;TIAN Xiao Li(Aging and Vascular Diseases,Human Aging Research Institute and School of Life Science,Jiangxi Key Laboratory of Human Aging,Nanchang University,Nanchang 330031,China)

机构地区：[1]南昌大学生命科学学院及人类衰老研究所江西省人类衰老重点实验室衰老与血管病研究室,南昌330031

出　　处：《中国科学：生命科学》2022年第2期123-137,共15页Scientia Sinica(Vitae)

基　　金：国家重点研发计划(批准号:2020YFC2002900);国家重点基础研究发展计划(批准号:2013CB530700);国家自然科学基金(批准号:81630034);江西省基础研究计划(批准号:20192ACB70002);江西省重点研发计划(批准号:20181ACB20017);江西省基地与人才计划(批准号:20181BCD40001)资助。

摘　　要：冠心病是一种常见的受遗传背景、生活习惯及环境等因素共同作用而导致的复杂疾病,其中遗传是重要的危险因素之一.目前通过全基因组扫描(连锁分析和关联分析)等技术已筛选到160余个冠心病易感位点和多个致病基因.本文主要介绍冠心病遗传机制的研究现状,致病基因所参与的生物学过程和信号通路,以及遗传与环境因素相互作用对冠心病发生和发展的影响;探讨通过冠心病遗传研究发现新的药物靶点的可能性;最后展望多因素综合作用研究,针对不同遗传背景对冠心病进行风险分级及精准医疗的问题和前景.Coronary artery disease(CAD)is a common disease caused by the interactions between genetic background and environments.Genetic determinant is one of the most important risk factors.By far,more than 160 susceptibility loci and several disease-causing genes have been identified through genome-wide scanning(linkage analysis and association analysis)and other techniques.Here,we summarize the CAD-associated loci,their biological processes and signaling pathways.The genome-wide gene-gene interactions as well as gene-environment interactions in the development of coronary artery disease and drug development are also discussed.Finally,we discuss the risk stratification of coronary artery disease and precision medical treatment based on different genetic backgrounds.

关 键 词：冠心病 危险因素 遗传 易感基因 基因-环境因素相互作用 

分 类 号：R541.4[医药卫生—心血管疾病]