香鳞毛蕨中1个新的间苯三酚苷类化合物  

A new phloroglucinol glycoside from Dryopteris fragrans

作　　者：韩旭阳[1,2] 曾祖平 何秀娟[1,2] 王宏 彭冰[1,2] HAN Xu-yang;ZENG Zu-ping;HE Xiu-juan;WANG Hong;PENG Bing(Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University,Beijing Institute of Traditional Chinese Medicine,Beijing 100010,China;Beijing Key Laboratory of Clinic and Basic Research with Traditional Chinese Medicine on psoriasis(BZ0375),Beijing 100010,China)

机构地区：[1]首都医科大学附属北京中医医院北京市中医药研究所,北京100010 [2]银屑病中医临床基础研究北京市重点实验室,北京100010

出　　处：《中草药》2022年第1期14-17,共4页Chinese Traditional and Herbal Drugs

基　　金：国家自然基金面上项目(81774312)。

摘　　要：目的研究香鳞毛蕨Dryopteris fragrans的化学成分。方法运用硅胶柱色谱、大孔吸附树脂柱色谱、Sephadex LH-20柱色谱及制备型HPLC等方法进行分离纯化,通过核磁共振、质谱等波谱学方法并结合文献对分离得到的化合物进行结构鉴定。结果从香鳞毛蕨水提物中分离得到6个化合物,分别鉴定为1-丁酰基-2-羟基-4-甲氧基-3-甲基间苯三酚-6-O-β-D-吡喃葡萄糖苷(1)、5,7-二羟基-2-甲基色原酮-7-O-β-D-葡萄糖苷(2)、monnierisides A(3)、异荭草素(4)、荭草素(5)和异牡荆黄素(6)。结论化合物1为新化合物,命名为绵马苷;化合物2、3、5、6为首次从该植物中分离得到。Objective To study the chemical constituents from the whole plants of Dryopteris fragrans. Methods The chemical constituents were isolated and purified by silica gel, macroporous adsorption resin, Sephadex LH-20 column chromatography, and preparative HPLC. The structures of the isolated compounds were identified by NMR and MS spectroscopic methods. Results Six compounds were isolated from the aqueous extract of D. fragrans, and identified as 1-butanoyl-2-hydroxy-4-methoxy-3-methylphloroglucinyl-6-O-β-D-glucopyranoside(1), 5,7-dihydroxy-2-methylchromone-7-O-β-D-glucoside(2), monnierisides A(3),isoorientin(4), orientin(5), and isovitexin(6). Conclusion Compound 1 is a new compound, named aspidinoloside, and compounds 2, 3, 5, 6 are isolated from this plant for the first time.

关 键 词：鳞毛蕨属 香鳞毛蕨 间苯三酚苷 绵马苷 荭草素 异牡荆黄素 

分 类 号：R284.1[医药卫生—中药学]