青藤碱免疫抑制作用机制的研究进展  

Research progress on immunosuppressive mechanism of sinomenine

作　　者：黄红 胡明月 徐丽[1] 易欧阳 苏昭丽 林也 张逢 邱峰 黄宇明 周华[3] 刘良[3] 蔡雄[1] HUANG Hong;HU Ming-yue;XU Li;YI Ou-yang;SU Zhao-li;LIN Ye;ZHANG Feng;QIU Feng;HUANG Yu-ming;ZHOU Hua;LIU Liang;CAI Xiong(Institute of Innovation and Applied Research in Chinese Medicine,Hunan University of Chinese,Changsha 410208,China;Hunan Zhengqing Pharmaceutical Group Co.,Ltd.,Huaihua 418000,China;State Key Laboratory of Quality Research in Chinese Medicine,Macao University of Science and Technology,Macao 999078,China)

机构地区：[1]湖南中医药大学中药粉体与创新药物省部共建国家重点实验室(培育基地),湖南长沙410208 [2]湖南正清制药集团股份有限公司,湖南怀化418000 [3]澳门科技大学中药质量研究国家重点实验室,中国澳门999078

出　　处：《中草药》2022年第1期261-269,共9页Chinese Traditional and Herbal Drugs

基　　金：湖南省科技创新重大项目(2020SK1020);湖南省“芙蓉学者奖励计划”资助项目(湘教通[2020]58号);湖南省121创新人才培养工程资助项目(湘人社函[2019]192号);湖南省“刘良院士专家工作站”资助项目(湘科协通[2020]34号);湖南中医药大学中医学国内一流建设学科项目(校行科字[2018]3号);湖南省中药粉体与创新药物省部共建国家重点实验室培育基地开放基金项目(科函[2018]4号)。

摘　　要：青藤碱是青藤Sinomenium acutum藤茎中的主要活性生物碱,具有显著的镇痛、抗炎、免疫抑制等药效作用,是一种应用前景良好的天然免疫抑制剂。大量研究表明青藤碱对众多免疫细胞(T细胞、单核/巨噬细胞、树突状细胞、肥大细胞)和免疫应答相关因子(细胞因子、活性氧、核因子-κB、细胞黏附分子)均具有免疫调节作用。通过综述近年来青藤碱免疫抑制作用的研究进展,以期为明确青藤碱作为自身免疫性疾病治疗药物的免疫抑制作用靶点,并揭示其作用信号通路途径提供研究思路。Sinomenine is a main bioactive alkaloid isolated from the stem of Sinomenium acutum. Sinomenine demonstrates significant analgesic, anti-inflammatory, and immunosuppressive effects, and has presented great potential as a naturally-derived immunosuppressive agent for autoimmune diseases. Many researches have shown that sinomenine exerts its immunosuppressive effects on various immune cells(T cells, monocytes/macrophages, dendritic cells and mast cells) and a number of immune response related factors(cytokines, reactive oxygen, nuclear factor-κB and cell adhesion molecules). Research progress on immunosuppressive mechanism of sinomenine are reviewed in this paper, so as to provide research ideas for identification of immunosuppressive target and signaling pathway of sinomenine as a treatment for autoimmune diseases.

关 键 词：青风藤 青藤碱 免疫抑制 自身免疫性疾病 免疫细胞 免疫应答相关因子 

分 类 号：R282.710.5[医药卫生—中药学]