基于斑马鱼模型的中药安全性评价研究进展  

Research progress on safety evaluation of traditional Chinese medicine based on zebrafish model

作　　者：范琦琦 李芝奇 陈美琳 赵崇军 林瑞超 FAN Qi-qi;LI Zhi-qi;CHEN Mei-lin;ZHAO Chong-jun;LIN Rui-chao(Beijing Key Laboratory for Quality Evaluation of Chinese Materia Medica,School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 102488,China)

机构地区：[1]北京中医药大学中药学院中药品质评价北京市重点实验室,北京102488

出　　处：《中草药》2022年第1期278-287,共10页Chinese Traditional and Herbal Drugs

基　　金：国家科技重大专项(2018ZX09735005);北京中医药大学新教师启动基金资助项目(2020-JYB-XJSJJ-009);北京中医药大学重点攻关项目(2020-JYB-ZDGG-035)。

摘　　要：毒性中药的临床使用是中医药的特色,在慢性疾病和重大疾病的救治过程中应用广泛。但是毒性中药的毒性研究数据相对较少,在一定程度上不能为系统阐述毒性中药的理论和临床安全使用提供充分的参考依据。中药配伍、炮制是中医药临床减毒增效的有效手段,准确而系统阐释配伍、炮制原理对中医药安全有效性至关重要。近年来,由于特定的生理学优势,斑马鱼已经逐步成为药物(中药)毒性研究的模型生物,逐步被用于各种有毒物质的筛选和评价。对近年来利用斑马鱼进行中药毒性评价、炮制减毒、配伍减毒及毒性机制研究等进行总结,以期为斑马鱼在中药毒性评价中的广泛应用和相关毒性标准的建立提供参考。The clinical use of toxic traditional Chinese medicine(TCM) is characteristic of TCM, and toxic TCM is used to treat various diseases with a wide application, especially for chronic diseases and serious diseases. However, the study data of toxic TCM are still insufficient, which can’t provide sufficient reference basis for systematic elaboration of toxic theoretical basis and clinical safe use of TCM.Compatibility and processing of TCM are effective means of reducing toxicity and enhancing efficacy in clinical practice. It is vital to accurately and systematically explain the influence of processing compatibility on the safety and effectiveness of TCM. In recent years,zebrafish has gradually become a model organism for studying the toxicity of drugs(including TCM) due to its specific physiological advantages. Therefore, zebrafish has been used in the toxicity screening and evaluation of various toxic substances. Toxic screening and assessment, processing and compatibility, and related mechanism of TCM based on zebrafish model are reviewed in this paper, in order to provide reference for wide application of zebrafish in the toxicity study of TCM and establishment of related toxicity standards.

关 键 词：中药 斑马鱼模型 毒性 安全性评价 炮制 配伍 减毒 

分 类 号：R285.51[医药卫生—中药学] R285.53[医药卫生—中医学]