基于内在成分含量差异辨别玄参药材品质优劣可行性研究  

Feasibility study on quality of Scrophulariae Radix based on chemical component quantitative difference analysis

作　　者：张勇纯 刘彦玲 王铭爽 李正坤 田悦[1] 孔娇 刘传鑫 王强 黄建梅[1] ZHANG Yong-chun;LIU Yan-ling;WANG Ming-shuang;LI Zheng-kun;TIAN Yue;KONG Jiao;LIU Chuan-xin;WANG Qiang;HUANG Jian-mei(School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 102488,China)

机构地区：[1]北京中医药大学中药学院,北京102488

出　　处：《中草药》2022年第2期544-556,共13页Chinese Traditional and Herbal Drugs

基　　金：国家中药标准化项目:复方血栓通胶囊标准化建设(ZYBZH-C-GD-06)。

摘　　要：目的以玄参Scrophularia ningpoensis为研究对象,分析药材中内在化学成分与其法定指标整体间的关联性,探讨以内在成分快速辨别药材品质优劣的可行性。方法取玄参药材按《中国药典》2020年版一部玄参项下测定,采用等权比值综合评分法对玄参药材进行品质优劣排序,使用色谱指纹图谱筛选共有成分并进行主成分分析,观察药材自然聚集趋势与品质优劣间关系,提出"以成分辨品质"试验假想并进行分析验证。结果不同来源玄参药材品质存在一定差异,等权综合比值评分法可有效表征玄参药材品质优劣,药材中内在化学成分与法定指标整体间具有一定关联性,验证试验有效。结论以内在成分含量差异对玄参药材进行品质优劣判别具有一定的可行性,可为玄参及其他部分中药材品质研究提供新思路和参考依据。Objective To analyze the correlation between the internal chemical components of the medicinal materials and their regulatory indicators by taking Chinese medicinal material Scrophulariae Radix as the research object, and to explore the feasibility of rapidly identifying the quality of the medicinal materials through their internal components. Methods Scrophulariae Radix was used to carry out the identification as directed in Chinese Pharmacopoeia 2020, Scrophulariae Radix. The equal weight ratio comprehensive scoring method was adopted to rank the quality of Scrophulariae Radix medicinal material. Chromatographic fingerprint was used to screen common components and complete the principal component analysis. The relationship between the natural aggregation tendency and the quality of medicinal material was observed and the experimental hypothesis of “identifying quality by components” was proposed and verified. Results There were some differences in the quality of Scrophulariae Radix medicinal material from different sources. Equal weight comprehensive ratio scoring method could effectively characterize the quality of Scrophulariae Radix medicinal material.There was a certain correlation between the internal chemical components of the medicinal materials and their regulatory indicators. The verification was valid. Conclusion It is feasible to judge the quality of Scrophulariae Radix medicinal material based on the difference in the content of the internal ingredients, which can provide new method and reference for the quality research of Scrophulariae Radix and other Chinese medicinal materials.

关 键 词：玄参 品质评价 内在成分 主成分分析 药典指标 哈巴苷 哈巴俄苷 

分 类 号：R286.2[医药卫生—中药学]