丹参化学成分、药理作用及其质量标志物(Q-Marker)的预测分析  

Chemical components and pharmacological action for Salviae Miltiorrhizae Radix et Rhizoma and predictive analysis on quality markers

作　　者：冯科冉 李伟霞[2,3] 王晓艳[2,3] 吴娅丽 张辉[2] 刘现磊[2] 陈毓龙 李琨 唐进法[2,3] FENG Ke-ran;LI Wei-xia;WANG Xiao-yan;WU Ya-li;ZHANG Hui;LIU Xian-lei;CHEN Yu-long;LI Kun;TANG Jin-fa(Henan University of Chinese Medicine,Zhengzhou 450046,China;Henan Province Engineering Laboratory for Clinical Evaluation Technology of Chinese Medicine,Henan Province Engineering Research Center of Clinical Application,Evaluation and Transformation of Traditional Chinese Medicine,Henan Provincial Key Laboratory for Clinical Pharmacy of Traditional Chinese Medicine,the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China;Provincial and Ministerial Construction Collaborative Innovation Center for Prevention and Treatment of Respiratory Diseases with Traditional Chinese Medicine,Henan University of Chinese Medicine,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学药学院,河南郑州450046 [2]河南中医药大学第一附属医院药学部,河南省中药临床应用、评价与转化工程研究中心,河南省中药临床药学中医药重点实验室,中药临床评价技术河南省工程实验室,河南郑州450000 [3]河南中医药大学呼吸疾病中医药防治省部共建协同创新中心,河南郑州450046

出　　处：《中草药》2022年第2期609-618,共10页Chinese Traditional and Herbal Drugs

基　　金：河南省科技攻关项目(202102310184);河南省中医药科学研究专项(20-21ZY1001);河南省中医药科学研究专项(20-21ZY2102);河南省中医药拔尖人才培养项目(豫中医科教[2018]35号)。

摘　　要：丹参因含丹参酮类、丹酚酸类、挥发油类、多糖类和含氮化合物等化学成分,具有抗凝血、抗炎、抗氧化、抗纤维化、抗肿瘤、保护脏器的作用,并在中药复方配伍和相关制剂中成为常用中药。在丹参化学成分和药理活性的基础上,从成分特有性、有效性、可测性、可入血成分及网络药理学预测5个不同角度对丹参质量标志物(quality marker,Q-Marker)进行分析预测,建议将6种酚酸类(丹参素、原儿茶醛、迷迭香酸、紫草酸、丹酚酸A和丹酚酸B)和4种丹参酮类(二氢丹参酮Ⅰ、隐丹参酮、丹参酮Ⅰ和丹参酮ⅡA)作为丹参Q-Marker的选择参考,以期为解决丹参质量问题建立更加科学的质量评价体系,为制定高水平的质量标准提供参考。Danshen(Salviae Miltiorrhizae Radix et Rhizoma) has the functions of anti-coagulation, anti-inflammation, anti-oxidation,anti-fibrosis, anti-tumor, liver protection because of its chemical components such as tanshinones, salvianolic acids, volatile oils,polysaccharides and nitrogen-containing compounds, it also has traditional Chinese medicine compound become a common traditional Chinese medicine in compatibility and related preparations. Based on the chemical components and pharmacological activities of Salviae Miltiorrhizae Radix et Rhizoma, the quality markers(Q-Marker) of Salviae Miltiorrhizae Radix et Rhizoma from five different perspectives: Component specificity, effectiveness, measurability, blood components and network pharmacology prediction are analyzed and predicted in this article. It is recommended to combine six phenolic acids(tanshinone, protocatechualdehyde, rosmarinic acid, shikonic acid, salvianolic acid A and salvianolic acid B) and four tanshinones(dihydrotanshinone Ⅰ, cryptotanshinone, tanshinone Ⅰ and tanshinone Ⅱ;) as a reference for the selection of Q-Marker of Salviae Miltiorrhizae Radix et Rhizoma, in order to establish a more scientific quality evaluation system for solving the quality problems of Salviae Miltiorrhizae Radix et Rhizoma and provide reference for formulating high-level quality standards.

关 键 词：丹参 质量标志物 丹参素 原儿茶醛 迷迭香酸 紫草酸 丹酚酸 二氢丹参酮I 隐丹参酮 丹参酮 抗凝血 抗炎 抗氧化 

分 类 号：R282.710.5[医药卫生—中药学]