免疫学标志物在1型糖尿病诊断及预测中的应用  

Application of immunological markers in the diagnosis and prediction of type 1 diabetes

作　　者：祁颜艳 杨涛[1] 顾愹[1] Qi Yanyan;Yang Tao;Gu Yong(Department of Endocrinology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学第一附属医院内分泌科,南京210029

出　　处：《中国医师杂志》2022年第2期190-195,共6页Journal of Chinese Physician

基　　金：国家自然科学基金(81770777,82170837);上海市医药卫生发展基金会糖尿病临床研究项目(Ⅰ期02研究)。

摘　　要：1型糖尿病(T1DM)是T细胞介导的器官特异性自身免疫疾病,未经治疗的T1DM病情可迅速恶化。早期预测及诊断可及早对患者进行治疗,改善患者预后。免疫系统在T1DM患者的β细胞破坏中起着重要作用,免疫标志物的出现为疾病的诊断和预测助了一臂之力。本文将结合数年来各种队列研究和临床研究的结果,从体液免疫标志物和细胞免疫标志物两个方面来综合探讨免疫学标志物在1型糖尿病预测及诊断中的应用。Type 1 diabetes mellitus(T1DM)is an organ-specific autoimmune disease mediated by T cells.Untreated T1DM deteriorate rapidly.Early prediction and diagnosis lead to early treatment and prognosis of patients.Immune system plays an important role in the destruction ofβcells in T1DM patients,and the emergence of immunological markers has facilitated the diagnosis and prediction of T1DM.Based on the results of various cohort studies and clinical studies in recent years,this review comprehensively discusses the application of immunological markers in the prediction and diagnosis of T1DM from two aspects:humoral immune markers and cellular immune markers.

关 键 词：糖尿病 1型 免疫学标志物 胰岛自身抗体 T淋巴细胞 

分 类 号：R587.1[医药卫生—内分泌]