丹参酮类脂溶性成分及其干预缺血性脑卒中机制的研究进展  

Research progress on liposoluble constituents of tanshinone and their intervention mechanisms in ischemic stroke

作　　者：王哲义 孙怿泽 邓欣祺 王春国[2] 田金洲[4] 卢涛 WANG Zhe-yi;SUN Yi-ze;DENG Xin-qi;WANG Chun-guo;TIAN Jin-zhou;LU Tao(Qilu Hospital,Shandong University,Jinan 250012,China;Beijing University of Chinese Medicine,Beijing 100029,China;School of Life Science,Beijing University of Chinese Medicine,Beijing 100029,China;Dongzhimen Hospital of Beijing University of Chinese Medicine,Beijing 100010,China)

机构地区：[1]山东大学齐鲁医院,山东济南250012 [2]北京中医药大学,北京100029 [3]北京中医药大学生命科学学院,北京100029 [4]北京中医药大学东直门医院,北京100010

出　　处：《中草药》2022年第4期1181-1190,共10页Chinese Traditional and Herbal Drugs

基　　金：北京市双一流高层次人才科研资助项目(1000041510053)。

摘　　要：缺血性脑卒中是一种由于脑部供血受阻导致缺血灶不可逆损伤的中枢神经系统疾病,其发病突然、传变迅速、病程复杂,静脉溶栓和血管内介入是早期干预的主要措施,但时间窗和禁忌症使其应用受到限制。丹参Salviae Miltiorrhizae Radix et Rhizoma为传统中药材,其中丹参酮类脂溶性成分治疗缺血性脑卒中疗效确切并在临床广泛应用。总结了丹参酮类脂溶性成分干预缺血性脑卒中的可能机制,包括抗凋亡、抗炎、调节自噬、限制谷氨酸兴奋性毒性、抑制氧化应激、促进新生血管形成等,以期为临床应用提供一定的借鉴。Ischemic stroke is a central nervous system disease that causes irreversible damage to the ischemic focus due to the obstruction of blood supply to the brain.It has a sudden onset,rapid transmission,and complex course.Intravenous thrombolysis and intravascular intervention are the main measures for early intervention.However,the time window and contraindications restrict its application.Danshen(Salviae Miltiorrhizae Radix et Rhizoma)is a traditional Chinese medicine of the motherland.Liposoluble constituents of tanshinone have a definite curative effect in treatment of ischemic stroke and are widely used in clinical practice.The possible mechanisms of tanshinone compounds intervention in ischemic stroke are summarized in this paper,including anti-apoptosis,anti-inflammation,regulating autophagy,limiting glutamate excitotoxicity,inhibiting oxidative stress,promoting neovascularization,etc.,in order to provide a certain reference for clinical application.

关 键 词：丹参 缺血性脑卒中 丹参酮ⅡA 丹参酮ⅡB 丹参酮Ⅰ 隐丹参酮 抗凋亡 抗炎 调节自噬 

分 类 号：R282.710.5[医药卫生—中药学]