中医药治疗阿片类药物所致便秘的研究进展  

Research progress on traditional Chinese medicine in treatment of opioid-induced constipation

作　　者：周稼荣 张铁军[2,3,4] 刘毅 陈金鹏[2,3,4] 刘志东 周思雨 廖茂良[2,3,4] 刘素香 李霞 高文远 田成旺[2,3,4] 陈常青 ZHOU Jia-rong;ZHANG Tie-jun;LIU Yi;CHEN Jin-peng;LIU Zhi-dong;ZHOU Si-yu;LIAO Mao-liang;LIU Su-xiang;LI Xia;GAO Wen-yuan;TIAN Cheng-wang;CHEN Chang-qing(Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Tianjin Institute of Pharmaceutical Research,Tianjin 300462,China;Tianjin Key Laboratory of Quality Marker of Traditional Medicine,Tianjin 300462,China;State Key Laboratory of Drug Delivery and Pharmacokinetics,Tianjin Institute of Pharmaceutical Research,Tianjin 300462,China;School of Pharmaceutical Science and Technology,Tianjin University,Tianjin 300072,China)

机构地区：[1]天津中医药大学,天津301617 [2]天津药物研究院,天津300462 [3]天津市中药质量标志物重点实验室,天津300462 [4]释药技术与药代动力学国家重点实验室,天津300462 [5]天津大学药物科学与技术学院,天津300072

出　　处：《中草药》2022年第4期1220-1229,共10页Chinese Traditional and Herbal Drugs

基　　金：国家重大新药创制专项(2019ZX09201005);国家自然科学基金青年项目(82003936)。

摘　　要：近年来癌症的发病率一直呈上升趋势,癌性疼痛是癌症患者治疗过程中的常见临床伴随症状。阿片类药物为中、重度疼痛治疗的首选药物,但是存在便秘、呕吐等不良反应。其中阿片类药物所致便秘(opioid-induced constipation,OIC)通常会存在于癌痛治疗的全过程,若不能得到有效解决,不但严重影响患者的癌症治疗效果,还给患者带来很大的痛苦。中医药治疗OIC临床疗效确切,临床应用广泛,常用的治疗手段有口服法、外治法、灌肠法及联合法等。围绕近年中医药在治疗OIC时的认识及应用进行综述,以期在OIC治疗过程中发挥更大价值。In recent years,the incidence of cancer has been on the rise,and cancer pain is a common clinical concomitant symptom in treatment of cancer patients.Opioids are the first choice for the treatment of moderate and severe pain,but there are many adverse reactions such as constipation and vomiting.Among them,opioid-induced constipation(OIC)usually exists in the whole process of cancer pain treatment,if it can’t be solved effectively,it will not only seriously affect the cancer treatment effect of patients,but also bring a lot of pain to patients.Traditional Chinese medicine is effective and widely used in treatment of OIC.The commonly used treatment methods are oral method,external treatment,enema method,and combination method and so on.The understanding and application of traditional Chinese medicine in treatment of OIC in recent years are reviewed in this paper,and in order to play a greater value in the process of treatment.

关 键 词：阿片类药物所致便秘 中医药 证型 口服法 外治法 灌肠法 联合法 

分 类 号：R282.710.5[医药卫生—中药学]