虎杖化学成分及药理活性研究进展  

Research development on chemical composition and pharmacology of Polygoni Cuspidati Rhizoma et Radix

作　　者：梁春晓 王珊珊[1] 陈淑静 王媛[1] 李晋[1] 常艳旭[1] LIANG Chun-xiao;WANG Shan-shan;CHEN Shu-jing;WANG Yuan;LI Jin;CHANG Yan-xu(State Key Laboratory of Component-based Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin301617,China)

机构地区：[1]天津中医药大学组分中药国家重点实验室,天津301617

出　　处：《中草药》2022年第4期1264-1276,共13页Chinese Traditional and Herbal Drugs

基　　金：国家重点研发计划(2020YFA0708004);国家重点研发计划(2019YFC1711000);天津市科技计划项目(21ZYJDJC00080)。

摘　　要：虎杖Polygoni Cuspidati Rhizoma et Radix在中国已有数千年治疗和预防疾病的历史,可用于改善腹泻、咳嗽、黄疸、炎症、闭经、烧伤和高脂血等症状。虎杖化学成分包括醌类、二苯乙烯类、黄酮类、苯丙素类等化合物。现代药理学和临床研究表明,虎杖可用于治疗炎症、糖尿病、痛风、癌症、病毒性疾病、细菌感染性疾病、神经退行性疾病等,尤其对冠状病毒引起的呼吸性疾病具有良好抑制作用。系统地总结了近几年虎杖的国内外研究文献,从化学成分及其药理作用的角度展开了综述,为虎杖药用资源进一步开发和应用提供依据,也为虎杖在抗击新型冠状病毒肺炎疫情中的应用提供科学依据。Huzhang(Polygoni Cuspidati Rhizoma et Radix)has been widely used to treat and prevent diseases in China for thousands of years.The therapeutic application of Polygoni Cuspidati Rhizoma et Radix is used for ameliorating diarrhea,cough,jaundice,inflammation,amenorrhea,burn and hyperlipemia,etc.Chemical compounds isolated and identified from this plant included quinones,stilbenes,flavonoids,and phenylpropanoids,etc.Recent pharmacological and clinical research experiments showed that Polygoni Cuspidati Rhizoma et Radix could be used for the treatment of diseases such as inflammation,diabetes,gout,cancer,viral diseases,bacterial infectious diseases,neurodegenerative diseases and other diseases.In particular,it has a good inhibitory effect on respiratory diseases caused by coronavirus.This article systematically summarizes the domestic and foreign research literatures of Polygoni Cuspidati Rhizoma et Radix in recent years,and reviews from the perspective of chemical components corresponding to the pharmacological effects,provides a basis for the further development and application of Polygoni Cuspidati Rhizoma et Radix medicinal resources,and also provides a scientific basis for the application of Polygoni Cuspidati Rhizoma et Radix in combating the new coronavirus pneumonia.

关 键 词：虎杖 蒽醌 二苯乙烯 虎杖苷 黄酮 苯丙素 

分 类 号：R282[医药卫生—中药学]