基于“生熟异用”何首乌的研究进展及其质量标志物(Q-Marker)的预测分析  

Research progress on Polygoni Multiflori Radix based on“raw and cooked with different uses”and prediction analysis on quality marker(Q-Marker)

作　　者：王卓 钟凌云[1] 解杨 宋金菊 李家晴 钟菁 WANG Zhuo;ZHONG Ling-yun;XIE Yang;SONG Jin-ju;LI Jia-qing;ZHONG Jing(School of Pharmacy,Jiangxi University of Chinese Medicine,Nanchang 330004,China)

机构地区：[1]江西中医药大学药学院,江西南昌330004

出　　处：《中草药》2022年第3期882-897,共16页Chinese Traditional and Herbal Drugs

基　　金：江西省双千人才计划项目(赣才办字[2019]9号)。

摘　　要：何首乌Polygoni Multiflori Radix是我国传统的补益类中药材,生品具有解毒消痈、截疟、润肠通便之效,炮制后具有补肝肾、益精血、乌须发、强筋骨功效,主要含有二苯乙烯苷类、蒽醌类、黄酮类、磷脂类、鞣质类等成分,其中二苯乙烯苷、儿茶素和没食子酸具有抗氧化、抗衰老、保肝等药理作用,糖类和卵磷脂类具有补益、调节免疫、抗肿瘤等药理作用,蒽醌类成分具有抑菌和泻下作用。目前,何首乌的质量评价方法较单一,故基于“生熟异用”理论,对何首乌炮制前后化学成分和药理作用的研究进展进行综述。从亲缘学与化学成分特有性、传统功效、传统药性、炮制相关、入血成分及药动学、调血脂、配伍等方面进行分析,二苯乙烯苷、大黄素、大黄素甲醚、没食子酸、何首乌多糖、卵磷脂、大黄素-8-O-β-D-葡萄糖苷、白藜芦醇等可作为其质量标志物(quality marker,Q-Marker),以期为何首乌的质量控制研究、临床用药及后续研究与开发提供参考。Heshouwu(Polygoni Multiflori Radix)is a traditional Chinese medicinal material for tonic in China.The raw product has the effects of detoxification,eliminating carbuncle,cutting malaria,moisturizing intestines and laxative.After processing,it has the effects of nourishing liver and kidney,nourishing essence and blood,blackening beard and hair,strengthening bones and muscles.It mainly contains stilbene glycosides,anthraquinones,flavonoids,phosphoesters,tannins and other ingredients.Among them,stilbene glycosides,catechins and gallic acid have anti-oxidation,anti-aging,liver protection and other pharmacological effects.Saccharides and lecithins have pharmacological effects such as tonic,immune regulation,anti-tumor,etc,and anthraquinones have antibacterial and laxative effects.At present,the quality evaluation method of Polygoni Multiflori Radix is relatively simple.Therefore,research progress on chemical composition and pharmacological effects of Polygoni Multiflori Radix based on“raw and cooked with different uses”are summarized in this paper.Phylogenetic relationship and specificity of chemical components,traditional efficacy,drug properties,processing-related,blood components and pharmacokinetics,regulating blood-lipid,and compatibility,etc are analyzed.Stilbene glycosides,emodin,emodin methyl ether,gallic acid,polysaccharides of Polygoni Multiflori Radix,lecithin,emodin-8-O-β-D-glucoside,resveratrol,etc.can be used as the components of its quality markers(Q-Marker),in order to provide reference for the quality control research,clinical medication and follow-up research and development of Polygoni Multiflori Radix.

关 键 词：何首乌 生熟异用 质量标志物 二苯乙烯苷 大黄素 大黄素甲醚 没食子酸 何首乌多糖 卵磷脂 大黄素-8-O-β-D-葡萄糖苷 白藜芦醇 

分 类 号：R282.710.5[医药卫生—中药学]