青风藤化学成分和药理作用的研究进展及其质量标志物(Q-Marker)的预测分析  

Research progress on chemical constituents and pharmacological effects of Sinomenii Caulis and predictive analysis on quality marker(Q-Marker)

作　　者：罗艳群 沈小兰 蔡三金[1] 梅志刚 冯知涛 LUO Yan-qun;SHEN Xiao-lan;CAI San-jin;MEI Zhi-gang;FENG Zhi-tao(College of Medicine,China Three Gorges University,Yichang 443002,China;College of Integrated Traditional Chinese and Western Medicine,Hunan University of Chinese Medicine,Changsha 410208,China;Third-grade Pharmacological Laboratory of Traditional Chinese Medicine,State Administration of Traditional Chinese Medicine,China Three Gorges University,Yichang 443002,China)

机构地区：[1]三峡大学医学院,湖北宜昌443002 [2]湖南中医药大学中西医结合学院,湖南长沙410208 [3]三峡大学国家中医药管理局中药药理科研三级实验室,湖北宜昌443002

出　　处：《中草药》2022年第3期898-911,共14页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81703783);湖北省医学青年拔尖人才项目(EWT2019-48)。

摘　　要：青风藤主要含有生物碱、挥发油、脂和甾体等活性成分。以青藤碱为代表的异喹啉类生物碱目前研究居多,其在风湿痹痛、关节肿痛、麻痹瘙痒中显示出良好的临床效果。青风藤在临床中应用越来越广泛,其质量评价方法亟需建立。根据中药质量标志物(quality marker,Q-Marker)新概念,从植物亲缘学和化学成分特有性、有效性、药性相关性、化学成分可测性等方面对青风藤Q-Marker进行预测分析,青藤碱、木兰花碱、蝙蝠葛任碱、左旋千金藤啶碱、千金藤宁碱、去甲乌药碱、尖防己碱等多种生物碱及挥发油、甾醇、蒽醌、菲及酚类物质可作为青风藤的主要Q-Marker,为青风藤质量评价体系的建立提供依据和相关新药研发提供参考。Qingfengteng(Sinomenii Caulis)mainly contains alkaloid,volatile oil,lipid,sterols and other active ingredients.Isoquinoline alkaloids represented by sinomenine are mostly studied at present and have a good clinical effect in rheumatic arthralgia,joint swelling and pain,paralysis pruritus.Sinomenii Caulis is more and more widely used in clinical application,and its quality evaluation also needs to be analyzed.According to the concept of quality marker(Q-Marker)of traditional Chinese medicine,QMarkers of Sinomenii Caulis were predicted and analyzed from the aspects of phylogenetic relationship and specificity of chemical components,efficacy,drug correlation,and measurability of chemical composition.Sinomenine,magnoflorine,menisperine,Lstepholidine,stephanine,higenamine,acutumine and other alkaloids,volatile oil,sterol,anthraquinone,phenanthrene and phenols can be used as the main Q-Markers of Sinomenii Caulis,which provide the basis for the establishment of quality evaluation system and reference for the research and development of related new drugs.

关 键 词：青风藤 青藤碱 木兰花碱 蝙蝠葛任碱 左旋千金藤啶碱 千金藤宁碱 去甲乌药碱 尖防己碱 

分 类 号：R282.710.5[医药卫生—中药学]