前胡与紫花前胡的化学成分和药理作用研究进展  

Research progress on chemical constituents and pharmacological activities of Peucedani Radix and Peucedani Decursivi Radix

作　　者：宋芷琪 李斌[2] 田琨宇 洪霖 吴威 张会永[1,4] SONG Zhi-qi;LI Bin;TIAN Kun-yu;HONG Lin;WU Wei;ZHANG Hui-yong(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China;Dalian Medical University,Dalian116044,China;Zhuhai College of Science and Technology,Zhuhai 519041,China;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,China)

机构地区：[1]辽宁中医药大学,辽宁沈阳110847 [2]大连医科大学,辽宁大连116044 [3]珠海科技学院,广东珠海519041 [4]辽宁中医药大学附属医院,辽宁沈阳110032

出　　处：《中草药》2022年第3期948-964,共17页Chinese Traditional and Herbal Drugs

基　　金：广东省自然科学基金项目(2021A1515011485);沈阳市中青年科技创新人才支持计划项目(RC190281)。

摘　　要：前胡和紫花前胡分别为伞形科植物白花前胡Peucedanum praeruptorum与紫花前胡P.decursivum的干燥根,为临床常用中药材,二者均含有香豆素类、黄酮类、挥发油类等多种化学成分,其中白花前胡活性成分以角型吡喃香豆素类化合物为主,而紫花前胡所含活性成分以线型呋喃香豆素为主。现代药理学研究表明,白花前胡主要具有抗心衰、降血压、抗心肌缺血等药理活性,而紫花前胡抗肿瘤、抗凝血作用更佳。虽在《中国药典》2020年版白花前胡和紫花前胡的功能主治描述相同,但从现代药学对2种前胡化学成分及药理作用研究进展来看,二者之间存在明显差异,故对白花前胡和紫花前胡的化学成分和药理作用进行系统总结,以期对2种常用前胡药材的现代临床应用及深入药效学机制研究提供参考。Qianhu(Peucedani Radix)and Zihuaqianhu(Peucedani Decursivi Radix)are the dried roots of Peucedanum praeruptorum and P.decursivum,respectively.Both of which contain similar chemical constituents,such as coumarins,flavonoids and volatile oil.However,the main active ingredients of Peucedani Radix and Peucedani Decursivi Radix are angular pyrancoumarins and linear furocoumarins,respectively.Modern pharmacology research showed Peucedani Radix exhibited a range of biological activities including anti-heart failure,antihypertensive and anti-myocardial ischemia;while Peucedani Decursivi Radix exhibited better anti-tumor and anticoagulant effects.Although the functions and indications of Peucedani Radix and Peucedani Decursivi Radixwere described in the same way in Chinese Pharmacopoeia,there were differences in the chemical constituents and pharmacological effects based on the data from the modern researches on them.In this review,the chemical constituents and pharmacological activities of Peucedani Radix and Peucedani Decursivi Radix were systematically summarized,in order to provide a reference for modern clinical applications and in-depth pharmacodynamic mechanism researches on the two commonly used Peucedanum medicinal materials.

关 键 词：白花前胡 紫花前胡 香豆素 抗心衰 降血压 抗凝血 抗癌 

分 类 号：R286[医药卫生—中药学]