高效孕激素联合化疗治疗子宫内膜癌的疗效及对患者血清肿瘤标志物和炎性因子的影响  

Efficacy of High-efficiency Progesterone Combined with Chemotherapy in the Treatment of Endometrial Cancer and its Influence on Serum Tumor Markers and Inflammatory Factors

作　　者：陈清香 CHEN Qingxiang(Department of Obstetrics,Affiliated Hospital of Putian University,Putian,Fujian Province,351100 China)

机构地区：[1]莆田学院附属医院产科,福建莆田351100

出　　处：《中外医疗》2022年第2期46-49,共4页China & Foreign Medical Treatment

摘　　要：目的研究子宫内膜癌患者采用高效孕激素联合化疗治疗后血清因子水平变化及临床疗效。方法2018年8月—2021年3月随机抽取该院妇科住院部收入治疗的80例子宫内膜癌患者进行分组研究,按随机奇偶原则划分组别,对照组40例单进行化疗治疗,研究组40例在化疗基础上联合高效孕激素治疗。治疗3个疗程后比较临床疗效、血清肿瘤标志物水平以及炎性因子水平。结果3个疗程后,研究组治疗总缓解率77.50%高于对照组52.50%,临床获益率92.50%高于对照组75.00%,差异有统计学意义(χ^(2)=5.495、4.501,P<0.05)。研究组人附睾蛋白4(HE4)、基质金属蛋白-9(MMP-9)、糖类抗原125(CA125)水平低于对照组,差异有统计学意义(t=12.824、6.646、8.017,P<0.05)。研究组肿瘤坏死因子-α(TNF-α)、白细胞介素6(IL-6)、C反应蛋白(CRP)水平低于对照组,差异有统计学意义(t=6.701、10.796、5.881,P<0.05)。结论高效孕激素联合化疗治疗子宫内膜癌可有效降低血清CA125、HE4、MMP-9水平,促进炎症吸收,有利于控制病情进展。Objective To study the changes in serum factor levels and clinical efficacy in patients with endometrial cancer treated with high-efficiency progesterone combined with chemotherapy.Methods A group study of 80 endometrial cancer patients who were randomly selected from the gynecological inpatient department for treatment from August 2018 to March 2021 in the hospital.The patients were divided according to the random odd-odd principle.40 cases in the control group received chemotherapy alone,and 40 cases in the study group were treated with high-efficiency progesterone on the basis of chemotherapy.After 3 courses of treatment,the clinical efficacy,serum tumor marker levels and inflammatory factor levels were compared.Results After 3 courses of treatment,the total remission rate of the study group was 77.50%higher than that of the control group 52.50%,and the clinical benefit rate was 92.50%higher than that of the control group 75.00%,the difference was statistically significant(χ^(2)=5.495,4.501,P<0.05).The levels of human epididymal protein 4(HE4),matrix metalloprotein-9(MMP-9)and carbohydrate antigen 125(CA125)in the study group were lower than those in the control group,and the differences were statistically significant(t=12.824,6.646,8.017,P<0.05).The levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),and C-reactive protein(CRP)in the study group were lower than those in the control group,and the differences was statistically significant(t=6.701,10.796,5.881,P<0.05).Conclusion High-efficiency progesterone combined with chemotherapy in the treatment of endometrial cancer can effectively reduce serum CA125,HE4,MMP-9 levels,promote inflammation absorption,and help control the progression of the disease.

关 键 词：子宫内膜癌 醋酸甲羟孕酮 化疗 血清肿瘤标志物 炎性因子 

分 类 号：R5[医药卫生—内科学]